The Pathophysiology of Preeclampsia and Eclampsia

Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time t...

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Bibliografische gegevens
Formaat:	Online
Taal:	Engels
Gepubliceerd in:	MDPI - Multidisciplinary Digital Publishing Institute 2023
Onderwerpen:	pre-eclampsia eclampsia pulmonary oedema biobank database placental ischemia seizure ASIC2a pregnancy RUPP pentylenetetrazol melatonin extracellular vesicle exosome preeclampsia misfold proteins endothelial cell activation p21Cip1/CDKN1A trophoblasts hypoxia trophoblast organoids fusion angiotensin II AGTR1 (angiotensin II receptor type 1) bradykinin BDKRB2 (bradykinin receptor B2) AT1R-B2R heteromer (protein complex formed of AT1R-B2R) G-protein-coupled receptor protein aggregation ARRB (beta-arrestin) early-onset preeclampsia hemorheology red blood cell aggregation red blood cell deformability erythrocyte hypertension IL-2 inflammation oxidative stress sFlt-1 NLRP3 nitric oxide endothelial dysfunction neuroinflammation blood–brain barrier cerebral edema gestation vessel blood pressure placenta trophoblast fetal growth restriction maternal chronic venous disease (CVeD) anti-inflammation antioxidant ischaemia vitamin E glucose transporter 9 GLUT9 uric acid cardiac dysfunction placental factors activin A G-protein-coupled receptors GPCR weighted gene correlation network analysis WGCNA blood-brain barrier in vitro studies cerebral biomarkers NfL tau NSE S100B nebivolol adrenoceptor obesity biomarkers adipokines adiponectin leptin ROS angiogenic factors hypoxia/reoxygenation sFlT-1/PlGF ratio primary trophoblast thema EDItEUR::M Medicine and Nursing
Online toegang:	ONIX_20230202_9783036564111_172
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The Pathophysiology of Preeclampsia and Eclampsia

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