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The Tight Junction and Its Proteins: More Than Just a Barrier

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discover...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:
tissue barrier
tight junction
claudins
tricellulin
tight junctions
organ preservation
intestine
transplantation
ischemia
intestinal mucosa
lung
epithelia
interleukin 13
UBE2Z
ubiquitin
osmolality
hydrostatic pressure
cancer
sensor
tricellular tight junctions
endometrial cancer
epithelial barrier dysfunction
Claudin-7
permeability
WNK4
epithelial sodium channel (ENaC), collecting duct cells
claudin-1
hydrogen peroxide
phosphorylation
claudin
angulin
drug development
angubindin-1
Clostridium perfringens enterotoxin
Clostridium perfringens iota-toxin
antibody
Mz-ChA-1 cells
biliary epithelial cells
phosphatidylcholine
mucus
paracellular transport
atopic dermatitis
cytokines
STAT3
ZO-2
cholestasis
gene transcription
hypertrophy
tumor suppressor
NLS
NES
CaSR
RhoA
barrier function
paracellular permeability
antidiuretic hormone
Claudin-14
CLDN14
hearing loss
vestibular function
cochlear implantation
Hepatitis C Virus
viral entry
epidermal barrier
reconstructed human epidermis
claudin targeting
Campylobacter jejuni
curcumin
apoptosis
co-culture
mouse colon
TNF
NFκB
lipolysis-stimulated lipoprotein receptor (LSR)
epithelial barrier
cell–cell contact
caspase
kidney stones
ion reabsorption
quercetin
brain barriers
blood-brain barrier
neurovascular unit
blood-cerebrospinal fluid barrier
arachnoid barrier
glia limitans
adherens junctions
paracellular sodium transport
thick ascending limb
nephropathy
HELIX syndrome
hypokalemia
hypermagnesemia
anhidrosis
gland dysfunction
aging
blood–brain barrier
mutations
kidney
liver
skin
human
mice
disease
in silico
drug discovery
membrane proteins
protein interactions
molecular dynamics
antibiotic-associated hemorrhagic colitis
Klebsiella oxytoca
tight junction assembly
monocytes
celiac disease
claudin-2
epithelium
inflammation
fibrosis
proliferation
migration
tricellular tight junction
paracellular water transport
tight epithelium
MDCK C7 cells
cell growth
endothelia
adherens junction
apical junctional complex
AMP-activated protein kinase (AMPK)
paracellular barrier
protein structure
protein domain
occludin
junctional adhesion molecule
zonula occludens
MAGUK proteins
PDZ domain
stem cell
chemoresistance
retinal pigment epithelium
retinopathy
barrier formation
collecting duct
claudin-5
neuropathic pain
nerve injury
dorsal root ganglion
enteropathogenic E. coli (EPEC)
tight junctions (TJ)
polarity
atypical aPKCζ
transepithelial electrical resistance (TER)
sorting nexin 9 (SNX9)
EspF
claudin 1
tumor
metastasis
epithelial to mesenchymal transition
cerebral cavernous malformation
endothelial barrier
Rho
ROCK
MEKK3
ion transport
ion channel
super-resolution microscopy
structured illumination microscopy
stimulated emission depletion
single molecule localization microscopy
Claudin
blood-biliary barrier
chronic liver disease
hepatocellular carcinoma
cholangiocellular carcinoma
NISCH syndrome
repair
NHE2
ClC-2
inflammatory bowel disease
mucosal immunology
ZO-1
actomyosin
aquaporin
drinking rate
epithelial fluid transport
enterocyte
osmoregulation
paracellular
proximal tubule
calcium permeability
claudin-12
paracellular channels and barriers
cell polarity
pathogens
immune cells
environmental sensors
thema EDItEUR::M Medicine and Nursing
Online Access:ONIX_20210501_9783039432240_1060
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