Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to t...

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Bibliographic Details

Main Authors:	Giovanni Blandino, Ygal Haupt
Format:	Online
Language:	English
Published:	Frontiers Media SA 2021
Subjects:	R5-920 RC254-282 mouse models mutant p53 dominant netagive therapies Oncogenic addiction gain of function thema EDItEUR::M Medicine and Nursing
Online Access:	18348
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