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PPARs as Key Mediators of Metabolic and Inflammatory Regulation

Mounting evidence suggests a bidirectional relationship between metabolism and inflammation. Molecular crosstalk between these processes occurs at different levels with the participation of nuclear receptors, including peroxisome proliferator-activated receptors (PPARs). There are three PPAR isotype...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
nuclear receptor
gene transcription
inflammation
molecular docking
PPARβ/δ
lung
pulmonary artery
GW0742
GSK3787
docking
lipopolysaccharide (LPS)
PPARγ ligand
coumarin
fluorescent ligand
screening
crystal structure
PPAR
atopic dermatitis
psoriasis
metabolic reprograming
glucose
fatty acids
mycobacteria
M. tuberculosis
M. leprae
PPARs
lipid droplets
metabolic alterations
hepatic damage
nuclear factors
pharmacological targets
AMPK
GDF15
insulin resistance
type 2 diabetes mellitus
peroxisome proliferator-activated receptor gamma (PPARγ)
real-time PCR
ELISA
immunohistochemistry
signaling pathway
PPAR gamma
brain
neural stem cells
infection
neuroinflammation
HIV
Zika
cytomegalovirus
neurogenesis
microglia
liver damage
toll-like receptor 4
P2Y2 receptor
metabolic syndrome
resveratrol
quercetin
PPARα
peroxisome
β-oxidation
PPRE
ligand
coregulator
micronutrients
PPARα knockout
adipose tissue
browning
lipid metabolism
depression
PPARg
neuropathology
corticotropin releasing hormone
norepinephrine
subgenual prefrontal cortex
amygdala
nucleus accumbens
common carotid artery occlusion
electroretinography
fibroblast growth factor 21
pemafibrate
peroxisome proliferator-activated receptor alpha
retinal ischemia
skeletal muscle
substrate metabolism
nonalcoholic fatty liver disease (NAFLD)
sex dimorphism
lipidomics
hepatic sex-biased gene expression
PPARγ
pulmonary arterial hypertension
TGFβ
vascular injury
proliferation
kidney fibrosis
pattern-recognition receptors
phagocytosis
nitric oxide synthase
fenofibrate
oleoylethanolamide
palmitoylethanolamide
cancer
immunity
obesity
diabetes
miRNA
DNA methylation
histone modification
peroxisome-proliferator-activated receptor
fatty acid oxidation
doping control
regulatory T cells
exercise
nuclear receptors
nutrigenomics
energy homeostasis
dairy animals
non-alcoholic fatty liver disease (NAFLD)
non-alcoholic steatohepatitis (NASH)
peroxisome proliferator-activated receptors (PPAR)
bezafibrate
fenofibric acid
peroxisome proliferator-activated receptor
dual/pan agonist
X-ray crystallography
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
Online Access:ONIX_20220621_9783036541921_14
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