Targeted Cancer Therapy and Mechanisms of Resistance

Tumor cells commonly exhibit dependence on a single activated oncogenic pathway or protein to maintain their malignant proliferation and survival, a phenomenon called “oncogene addiction”. According to this concept, protein kinases have been identified as promising molecular targets for cancer thera...

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Bibliografske podrobnosti
Format:	Online
Jezik:	angleščina
Izdano:	MDPI - Multidisciplinary Digital Publishing Institute 2022
Teme:	3D spheroids photothermy gold nanoparticles doxorubicin resistance colorectal cancer cellular prion protein PrPC PRNP cancer cancer stem cell targeted cancer therapy brain metastases treatment non-small cell lung carcinoma EGFR ALK immunotherapy HDAC6 bortezomib-resistance HDAC6-selective inhibitor bortezomib carfilzomib multiple myeloma LMP2 combination therapy colorectal cancer cells drug resistance 5-Fluorouracil thymidylate synthase exome sequencing CD47 immune activation pro-tumoral macrophages breast cancer polo-like kinase 1 (PLK1) pyrazole quantitative structure-activity relationship hybridization ovarian cancer cisplatin cisplatin resistance PARPi niraparib Twist lethality AF4 cell culture FGFR2 HOXA9 MLL-AF4 nucleus target therapy t(4 11) leukemia radiation-resistant cell death ERK EMT cancer stem cells (CSCs) PD98059 PARP inhibitors PARP inhibitor resistance signal transduction networks pathways event-free survival biomarkers WNT pathway targeted therapy Wee1 kinase cell cycle tumor resistance lenvatinib sorafenib-resistant hepatocellular carcinoma FGFR4 autophagy microRNA thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online dostop:	ONIX_20220224_9783036528564_33
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Targeted Cancer Therapy and Mechanisms of Resistance

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