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Drug-Drug Interactions

Drug–drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have bee...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
tadalafil
ticagrelor
drug-drug interaction
pharmacokinetics
plasma concentration
CYP3A4
Loxoprofen
CYP3A
Dexamethasone
Ketoconazole
CYP2D6
O-desmethyltramadol
physiologically-based pharmacokinetics
tramadol
(‒)-sophoranone
CYP2C9
potent inhibition
in vitro
in vivo
drug interaction
low permeability
high plasma protein binding
biflavonoid
cytochrome P450
drug interactions
selamariscina A
uridine 5′-diphosphoglucuronosyl transferase
tissue-specific
systemic exposure
P-glycoprotein (P-gp)
organic anion transporting polypeptide 1A2 (OATP1A2)
Rumex acetosa
fexofenadine
chronic kidney disease
drug–drug interactions
polypharmacy
adverse drug reactions
Lexicomp
subset analysis
signal detection algorithms
spontaneous reporting systems
mechanism-based inhibition
competitive inhibition
non-competitive inhibition
substrate
inhibitor
cytochromes P450
OATP1B1
OATP1B3
tyrosine kinase inhibitors
drug-drug interactions
migraine
lasmiditan
gepants
monoclonal antibodies
CYP1A1
CYP1A2
drug–drug interaction
expression
metabolism
regulation
drug transporter
ubiquitination
ixazomib
DDI
computational prediction
in silico
QSAR
drug metabolism
ADME
CYP
metabolic DDI
P450
1A2
2B6
2C19
2C8
2C9
2D6
3A4
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:ONIX_20220111_9783036520353_606
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