Human African Trypanosomiasis (Sleeping Sickness)

As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spect...

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Bibliographic Details
Format:	Online
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:	(+)-spectaline iso-6-spectaline Trypanosoma brucei rhodesiense autophagy apoptosis cross-talk trypanosomosis iron transferrin transferrin receptor nutritional immunity flagellar pocket Human African Trypanosomiasis (HAT) mydriasis neurological signs eradication re-emergence human African trypanosomiasis treatment melarsoprol adverse event encephalopathy human leukocyte antigen association study disease elimination disease eradication frontline workers DR Congo mobile screening qualitative methods sequelae serology oligosymptomatic HAT product development partnerships research and development medical innovation donor policy African trypanosomiasis sleeping sickness trypanosoma brucei drugs drug resistance history human Africa trypanosomiasis fexinidazole home-based treatment patient-centred care Uganda elimination T. b. gambiense g-HAT T. b. rhodesiense r-HAT neglected tropical diseases Trypanosoma brucei drug discovery high-throughput screening blood–brain barrier brain permeability pharmacology phenotypic drug screening Haemoparasites animal reservoirs Trypanosoma growth inhibitors chemotherapy pafuramidine acoziborole African sleeping sickness development of treatment suramin medical history political history clinical research health system strengthening South Sudan diagnosis symptoms treatment-seeking case detection embodiment expertise serendipity CATT positive serological suspects active follow-up strategy n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBN Public health and preventive medicine::MBNS Epidemiology and Medical statistics
Online Access:	ONIX_20210501_9783039289639_370
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Human African Trypanosomiasis (Sleeping Sickness)

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