Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following cri...

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Egile Nagusiak:	Denton, Helen, Major, Louise L., Smith, Terry K.
Formatua:	Online
Hizkuntza:	ingelesa
Argitaratua:	InTechOpen 2021
Gaiak:	pharmacology toxicology Assay Enzyme Molar concentration Protein Thermal shift assay Trypanosoma brucei thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
Sarrera elektronikoa:	627366
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