Inhibiting PARP as a Strategic Target in Cancer

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have...

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Bibliographic Details

Main Authors:	Kristin Zorn, Christina Annunziata
Format:	Online
Language:	English
Published:	Frontiers Media SA 2021
Subjects:	R5-920 RC254-282 DNA reapir PARP inhibitor Homologous Recombination combination therapy DNA Damage Cancer thema EDItEUR::M Medicine and Nursing
Online Access:	18342
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