Neurodegenerative Disease: From Molecular Basis to Therapy

Neurodegenerative diseases are a heterogeneous, largely age-related group of disorders, characterised by the progressive degeneration or death of neurons in the central or peripheral nervous system. The prevalence of these diseases is increasing, in part due to the ageing of the population, with a c...

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Bibliographic Details
Format:	Online
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2024
Subjects:	Alzheimer’s disease toxic amyloids Aβ tau genetics amyloid clearance vascular dysfunction neuroinflammation heat shock proteins drug targets glutathione oxidative stress redox signaling glyceraldehyde-3-phosphate dehydrogenase hydrogen peroxide neurodegenerative disease molecular dynamic simulation Parkinson’s disease deep brain stimulation adaptive stimulation multi-site stimulation thalamocortical relay basal ganglia model local field potential Huntington’s disease lysosome NAADP two-pore channels diabetic neuropathy neurological damage during delivery depression macronutrients mineral elements appropriate supplementation overdose or deficiency andrographolide MPP+ SH-SY5Y cells ROS Nrf2 mitophagy protein aggregates proteostasis aging age-related neurodegenerative diseases autophagy ubiquitin-proteasome system ARL6IP5 (ADP-ribosylation-like factor 6 interacting protein 5) Parkinson’s disease (PD) neurodegeneration α-synuclein LAR astrocyte mitochondrial function neuron rotenone dementia cognition peripheral blood algorithm early diagnosis experimental models of neurological diseases vitamin E alpha tocopherol experimental models psychosis dopamine ventral hippocampus parvalbumin α5-GABAA the amyloid cascade hypothesis 2.0 (ACH2.0) intraneuronal Aβ (iAβ) Aβ protein precursor (AβPP)-independent generation of iAβ aging-related cognitive dysfunction (AACD) iAβ depletion therapy for AD and AACD BACE1 and BACE2 activators as AD and AACD drugs brain transcriptome migratory birds spring migration wintering Calidris pusilla PKCε PRKCE amyotrophic lateral sclerosis Bryostatin-1 methamphetamine substantia nigra pars compacta locus coeruleus monoamine oxidase sex difference α7 nicotinic acetylcholine receptor TLR4 TLR2 CXCR4 CD4 CCR5 TR-FRET amyloid precursor protein (APP) amyloid beta protein biogenesis protein transport membrane proteins SRP-dependent targeting n/a thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:	ONIX_20240514_9783725801886_155
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Neurodegenerative Disease: From Molecular Basis to Therapy

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