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Neurodegenerative Disease: From Molecular Basis to Therapy

Neurodegenerative diseases are a heterogeneous, largely age-related group of disorders, characterised by the progressive degeneration or death of neurons in the central or peripheral nervous system. The prevalence of these diseases is increasing, in part due to the ageing of the population, with a c...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2024
Subjects:
Alzheimer’s disease
toxic amyloids
Aβ
tau
genetics
amyloid clearance
vascular dysfunction
neuroinflammation
heat shock proteins
drug targets
glutathione
oxidative stress
redox signaling
glyceraldehyde-3-phosphate dehydrogenase
hydrogen peroxide
neurodegenerative disease
molecular dynamic simulation
Parkinson’s disease
deep brain stimulation
adaptive stimulation
multi-site stimulation
thalamocortical relay
basal ganglia model
local field potential
Huntington’s disease
lysosome
NAADP
two-pore channels
diabetic neuropathy
neurological damage during delivery
depression
macronutrients
mineral elements
appropriate supplementation
overdose or deficiency
andrographolide
MPP+
SH-SY5Y cells
ROS
Nrf2
mitophagy
protein aggregates
proteostasis
aging
age-related neurodegenerative diseases
autophagy
ubiquitin-proteasome system
ARL6IP5 (ADP-ribosylation-like factor 6 interacting protein 5)
Parkinson’s disease (PD)
neurodegeneration
α-synuclein
LAR
astrocyte
mitochondrial function
neuron
rotenone
dementia
cognition
peripheral blood
algorithm
early diagnosis
experimental models of neurological diseases
vitamin E
alpha tocopherol
experimental models
psychosis
dopamine
ventral hippocampus
parvalbumin
α5-GABAA
the amyloid cascade hypothesis 2.0 (ACH2.0)
intraneuronal Aβ (iAβ)
Aβ protein precursor (AβPP)-independent generation of iAβ
aging-related cognitive dysfunction (AACD)
iAβ depletion therapy for AD and AACD
BACE1 and BACE2 activators as AD and AACD drugs
brain transcriptome
migratory birds
spring migration
wintering
Calidris pusilla
PKCε
PRKCE
amyotrophic lateral sclerosis
Bryostatin-1
methamphetamine
substantia nigra pars compacta
locus coeruleus
monoamine oxidase
sex difference
α7 nicotinic acetylcholine receptor
TLR4
TLR2
CXCR4
CD4
CCR5
TR-FRET
amyloid precursor protein (APP)
amyloid beta
protein biogenesis
protein transport
membrane proteins
SRP-dependent targeting
n/a
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:ONIX_20240514_9783725801886_155
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