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Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

Although DNA repair enzymes play a crucial role in maintaining the integrity of the genome, the hyperactivity of certain enzymes of the DNA repair system can lead to the resistance of tumors to chemo- and radiotherapy, aimed at damaging the DNA of cancer cells. Therefore, the inhibition of DNA repai...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2023
Soggetti:
poly (ADP-ribose) polymerase inhibitor
non-small cell lung cancer
DNA damage
radiotherapy
chemotherapy
combination therapy
coumarin
neoflavone
DNA repair enzymes
Tdp1 inhibitor
cancer
tumor
topotecan
topoisomerase 1 inhibitors
molecular modeling
chemical space
morpholino nucleosides
NAD+ analogs
DNA repair
PARP
7-methylguanine
poly(ADP-ribose) polymerase 1
inhibitor
nucleosome
trapping
docking
molecular dynamics
fluorescence anisotropy
spFRET microscopy
DNA glycosylases
drug targets
APE1
protein–protein interactions
base excision repair
multifunctional disordered protein
fluorescence techniques
cell cycle checkpoint
cancer therapy
DNA repair inhibitors
synthetic lethality
fused in sarcoma
poly(ADP-ribose) polymerase
poly(ADP-ribose)
protein phase separation
berberine
tetrahydroberberine
DNA repair enzyme
SAR
poly(ADP-ribosylation)
PARP-1
Olaparib
KU55933
KU-0060648
SCR7 pyrazine
VERO cells
synergism
resistance
CDKN2A
soft tissue sarcomas (STS)
gastrointestinal stromal tumors (GIST)
AKT signaling
Rad51 recombinase
homology-mediated DNA repair
apoptosis
sensitization
XPA
ERCC1-XPF
CSB
UVB radiation
UVB mutagenesis
nucleotide excision repair (NER)
cyclobutane–pyrimidine dimer (CPD) photolesion
veliparib
resveratrol
arsenic trioxide
spironolactone
usnic acid
thioether
tyrosyl-DNA phosphodiesterase 1
TDP1 inhibitor
inhibiting activity
TDP2
PARP1
synergy
HEK293 knockout cell line
polyphenols
PARP-1 inhibitors
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Accesso online:ONIX_20230714_9783036578811_72
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