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Frontiers of Targeted Therapy and Predictors of Treatment Response in Systemic Sclerosis

Systemic sclerosis (scleroderma) is an incurable connective tissue disease with an unclear etiology characterized by vasculopathy, dysregulation of the immune response, and progressive tissue fibrosis affecting the skin, lungs, digestive tract, heart, and kidneys. The collection of six original rese...

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Autor principal: Herrington, Gaya
Formato: Online
Idioma:inglês
Publicado em: MDPI - Multidisciplinary Digital Publishing Institute 2023
Assuntos:
heat shock protein 90
systemic sclerosis
established dermal fibrosis
treatment
pathogenesis
epigenetic mechanisms
miRNAs
calcinosis cutis
bisphosphonates
pamidronate
autoimmune connective tissue diseases
dermatomyositis
immune cells
anti-inflammatory
therapy
fibrosis
interleukin-6
Tocilizumab
pulmonary fibrosis
interstitial lung disease
progressive fibrosing interstitial lung disease
lung function
body mass index
clinical trial
metabolomics
LC-MS/MS
ion mobility
kynurenine pathway
urea cycle
lipids
gut dysbiosis
pulmonary arterial hypertension (PAH)
biomarkers
miRNA
complement
myofibroblasts
macitentan
cough
pulmonary hypertension
predictors of treatment response
autoreactive B cells
autoantibodies
rituximab
aptamers
Seldeg
n/a
mixed connective tissue disease
systemic lupus erythematosus
Sjögren’s syndrome
rheumatoid arthritis
idiopathic inflammatory myopathy
national delphi consensus
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Acesso em linha:ONIX_20230202_9783036561219_35
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