Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer

This Special Issue comprises 15 papers broadly outlining current trends in nucleic acid biophysics. It contains original research papers and reviews on structure, stability, and interactions of canonical and non-canonical nucleic acids. The authors describe the use of established, time-honored exper...

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Médium:	Online
Jazyk:	angličtina
Vydáno:	MDPI - Multidisciplinary Digital Publishing Institute 2023
Témata:	nucleic acid structures nucleic acid conformation biological structure database DNA RNA validation standards G-quadruplex replication thermodynamics ligand topology quadruplex-duplex hybrids minor groove binding drugs stability optical spectroscopy nucleic acids charge electrostatic potential ab initio methods NMR spectroscopy molecular dynamics forcefield AMBER B-DNA DNA-hairpin perchlorates brines pressure Mars habitability DNA minor groove binder mixed base-pair DNA sequences sequence selectivity ligand–DNA complex thermodynamic molecular curvature heterocyclic diamidine biosensor calorimetry DNA conjugate metal ion triple helix silver ion lanthanide ATP sensor aptamer terpyridine sequence edition DNAzyme molecular dynamics simulation (MD) potential of mean force (PMF) dsDNA–dsDNA interactions flexibility origins of life DNA-protein networks protocells DNA sequence-dependent structure DNA deformability DNA sequence context DNA curvature DNA minicircles hydrostatic pressure volume CD spectroscopy G-quadruplexes potassium polymorphism kinetics folding kinetic models fitting aurintricarboxylic acid (ATA) salicylic acid polymers methylene-salicylic acid SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) yeast ribosomes human serum albumin (HSA) molecular recognition biological function and viral disease inhibitor binding single-molecule biophysics nucleic acid thermodynamics statistical mechanics fluctuation theorems computational biophysics n/a drug discovery drug-target interactions thermodynamic binding signatures isothermal titration calorimetry lead optimization fragment-based drug discovery drug-like properties enthalpic efficiency group efficiency lipophilic efficiency thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
On-line přístup:	ONIX_20230202_9783036560984_29
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Biophysics of Nucleic Acids Celebrating the 75th Birthday of Professor Kenneth J. Breslauer

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