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Recent Advances in the Synthesis, Functionalization and Applications of Pyrazole-Type Compounds I

Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®)...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
pyrazolopyridopyridazine dione
N-aminopyrazolopyrrolopyridine dione
luminol
photoluminescence
pyrazole
coumarin
antimicrobial
hydrazone
biofilm
Staphylococcus aureus
S. epidermidis
MRSA
pyrazolyl-ureas
pyrazole nucleus
protein kinase inhibitors
anti-inflammatory agents
anticancer agents
anti-pathogens agents
nitrated pyrazoles-based
energetic salts
synthesis
high energy density material
insensitivity
amination
4-halopyrazole
Buchwald-Hartwig coupling
Pd(dba)2
CuI mediated coupling
aliphatic amine
X-ray
pyrazolate
coinage metals
metallacycles
M06-2x
pyrazolyl-s-triazine
Fe(III)
self-assembly
Hirshfeld
antimicrobial activity
pyrazoles
styrylpyrazoles
biological activity
organic synthesis
reactivity
homocoupling
bipyrazole
transition-metal catalysts
metal–organic frameworks
1,3-dipolar cycloadditions
2,3-dihydropyrazolo[1,2-a]pyrazoles
copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC)
azomethine imines
ynones
bis(pyrazol-1-yl)alkanes
carboxylation
oxalyl chloride
dicarboxylic acids
alkylation
superbasic medium
1,2,4-oxadiazoles
spiropyrazolinium compounds
in vitro antitubercular screening
X-ray diffraction
molecular docking
polynuclear
silver
crystal structure
pyrazolate ligand
coordination polymer
functionalization
heterocyclic
neurodegeneration
Alzheimer’s disease
Parkinson’s disease
inhibitor
antagonist
antitumor scaffold
enzymatic inhibitory
N-heterocyclic compounds
pyrazolo[1,5-a]pyrimidine
pyrazolo[1,5-a]pyrimidines
aromatic substitution
electrooxidation
C–H halogenation
C–H thiocyanation
N–N coupling
cyclic voltammetry
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PN Chemistry
thema EDItEUR::P Mathematics and Science::PN Chemistry::PNN Organic chemistry
Online Access:ONIX_20221117_9783036554211_6
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