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Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing

Biopharmaceutical and pharmaceutical manufacturing are strongly influenced by the process analytical technology initiative (PAT) and quality by design (QbD) methodologies, which are designed to enhance the understanding of more integrated processes. The major aim of this effort can be summarized as...

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Formato: Online
Idioma:inglês
Publicado em: 2022
Assuntos:
clonal cell population
phenotypic diversity
inoculum train
uncertainty-based
cell culture model
biopharmaceutical manufacturing
Escherichia coli
hybrid modeling
machine learning
model-assisted DoE
quality by design
upstream bioprocessing
surface plasmon resonance (SPR)
bioprocess
monitoring
biosensor
quality by design (QbD)
process analytical technology (PAT)
biotherapeutics production
vaccines production
CHO DP-12
computational fluid dynamics
bioreactor characterization
hydrodynamic gradients
process development
critical shear stress
Kolmogorov length scale
operational space
sensors
cell culture
spectroscopy
PAT
smart biomanufacturing
soft-sensor
Adeno-associated virus
transfection
PEI
continuous
gene therapy
microcarriers
bioreactor
transient expression
spheroid strength
β-cells
diabetes
shear stress-guided production
hydrodynamic stress
Gaussian processes
Bayes optimization
Pareto optimization
multi-objective
seed train
Chinese hamster ovary cells
cryopreservation
monoclonal antibodies
N−1 perfusion
process intensification
upstream processing
n/a
thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
Acesso em linha:ONIX_20220916_9783036552101_128
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