Role of MicroRNA in Cancer Development and Treatment
Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Canc...
I tiakina i:
| Hōputu: | Online |
|---|---|
| Reo: | Ingarihi |
| I whakaputaina: |
MDPI - Multidisciplinary Digital Publishing Institute
2022
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| Ngā marau: | |
| Urunga tuihono: | ONIX_20220621_9783036538068_28 |
| Ngā Tūtohu: |
Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!
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| _version_ | 1863743790652588032 |
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| collection | Directory of Open Access Books |
| description | Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Cancer cells with abnormal miRNA expression evolve the capability to sustain proliferative signaling, evade growth suppressors, resist cell death, activate invasion and metastasis, and induce angiogenesis. Genome-wide profiling demonstrates that miRNA expression signatures are associated with tumor type, tumor grade and clinical outcomes, so miRNAs could be potential candidates for diagnostic biomarkers, prognostic biomarkers, therapeutic targets and preventive screening programs. Although miRNAs have multiple targets, their function in tumorigenesis is due to their regulation of a few specific targets. After the first detection of altered miRNA in leukemia, microRNAs have been demonstrated to be constantly altered in all cancer. More recently, microRNA has been shown to be altered by exposure to environmental carcinogens, thus driving the whole process of carcinogenesis. Our aim is to provide a rigorous peer review and publish cutting-edge research on the role of microRNA in cancer prevention therapy to educate and inspire the scientific community worldwide. |
| format | Online |
| id | doab-20.500.12854ir-84450 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-844502024-03-31T13:08:13Z Role of MicroRNA in Cancer Development and Treatment Pulliero, Alessandra Izzotti, Alberto breast cancer miRNAs liquid biopsy angiogenesis biomarkers early diagnosis air pollution biomarker exposure human lung cancer miRNA carcinogenesis microRNA asbestos exposure oral squamous cell carcinoma diagnosis prognosis saliva neuroblastoma MYCN amplification metastases chemoresistance public health genomics genetic polymorphisms epigenetic modulations genetic and microbiome markers health technology assessment early disease prevention nonsmokers lung cancer environmental risk factors oncogenes mutations glioblastoma microRNAs cancer qPCR cancer stem cells plasticizers in vitro study PRISMA no-smokers lung cancer DNA adducts mesothelioma extracellular vesicles miR-625 fluoro-edenite asbestos malignant mesothelioma cancer prevention microbiota epigenetics environmental pollutants cutaneous tissues ozone exposure n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Many researchers around the world have demonstrated that the expression of miRNAs is dysregulated in different tumors. Such dysregulation is caused by multiple mechanisms, and exposure to different carcinogens causes dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. Cancer cells with abnormal miRNA expression evolve the capability to sustain proliferative signaling, evade growth suppressors, resist cell death, activate invasion and metastasis, and induce angiogenesis. Genome-wide profiling demonstrates that miRNA expression signatures are associated with tumor type, tumor grade and clinical outcomes, so miRNAs could be potential candidates for diagnostic biomarkers, prognostic biomarkers, therapeutic targets and preventive screening programs. Although miRNAs have multiple targets, their function in tumorigenesis is due to their regulation of a few specific targets. After the first detection of altered miRNA in leukemia, microRNAs have been demonstrated to be constantly altered in all cancer. More recently, microRNA has been shown to be altered by exposure to environmental carcinogens, thus driving the whole process of carcinogenesis. Our aim is to provide a rigorous peer review and publish cutting-edge research on the role of microRNA in cancer prevention therapy to educate and inspire the scientific community worldwide. 2022-06-21T08:36:26Z 2022-06-21T08:36:26Z 2022 book ONIX_20220621_9783036538068_28 9783036538068 9783036538051 https://directory.doabooks.org/handle/20.500.12854/84450 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/5433 https://mdpi.com/books/pdfview/book/5433 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-3805-1 10.3390/books978-3-0365-3805-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036538068 9783036538051 280 Basel open access |
| spellingShingle | breast cancer miRNAs liquid biopsy angiogenesis biomarkers early diagnosis air pollution biomarker exposure human lung cancer miRNA carcinogenesis microRNA asbestos exposure oral squamous cell carcinoma diagnosis prognosis saliva neuroblastoma MYCN amplification metastases chemoresistance public health genomics genetic polymorphisms epigenetic modulations genetic and microbiome markers health technology assessment early disease prevention nonsmokers lung cancer environmental risk factors oncogenes mutations glioblastoma microRNAs cancer qPCR cancer stem cells plasticizers in vitro study PRISMA no-smokers lung cancer DNA adducts mesothelioma extracellular vesicles miR-625 fluoro-edenite asbestos malignant mesothelioma cancer prevention microbiota epigenetics environmental pollutants cutaneous tissues ozone exposure n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Role of MicroRNA in Cancer Development and Treatment |
| title | Role of MicroRNA in Cancer Development and Treatment |
| title_full | Role of MicroRNA in Cancer Development and Treatment |
| title_fullStr | Role of MicroRNA in Cancer Development and Treatment |
| title_full_unstemmed | Role of MicroRNA in Cancer Development and Treatment |
| title_short | Role of MicroRNA in Cancer Development and Treatment |
| title_sort | role of microrna in cancer development and treatment |
| topic | breast cancer miRNAs liquid biopsy angiogenesis biomarkers early diagnosis air pollution biomarker exposure human lung cancer miRNA carcinogenesis microRNA asbestos exposure oral squamous cell carcinoma diagnosis prognosis saliva neuroblastoma MYCN amplification metastases chemoresistance public health genomics genetic polymorphisms epigenetic modulations genetic and microbiome markers health technology assessment early disease prevention nonsmokers lung cancer environmental risk factors oncogenes mutations glioblastoma microRNAs cancer qPCR cancer stem cells plasticizers in vitro study PRISMA no-smokers lung cancer DNA adducts mesothelioma extracellular vesicles miR-625 fluoro-edenite asbestos malignant mesothelioma cancer prevention microbiota epigenetics environmental pollutants cutaneous tissues ozone exposure n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | breast cancer miRNAs liquid biopsy angiogenesis biomarkers early diagnosis air pollution biomarker exposure human lung cancer miRNA carcinogenesis microRNA asbestos exposure oral squamous cell carcinoma diagnosis prognosis saliva neuroblastoma MYCN amplification metastases chemoresistance public health genomics genetic polymorphisms epigenetic modulations genetic and microbiome markers health technology assessment early disease prevention nonsmokers lung cancer environmental risk factors oncogenes mutations glioblastoma microRNAs cancer qPCR cancer stem cells plasticizers in vitro study PRISMA no-smokers lung cancer DNA adducts mesothelioma extracellular vesicles miR-625 fluoro-edenite asbestos malignant mesothelioma cancer prevention microbiota epigenetics environmental pollutants cutaneous tissues ozone exposure n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20220621_9783036538068_28 |