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Mechanisms of ER Protein Import

Protein import into the endoplasmic reticulum (ER) is the first step in the biogenesis of approximately 10,000 different soluble and membrane proteins of human cells, which amounts to about 30% of the proteome. Most of these proteins fulfill their functions either in the membrane or lumen of the ER...

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Format: Online
Language:English
Published: MDPI - Multidisciplinary Digital Publishing Institute 2022
Subjects:
chaperones
contact sites
endoplasmic reticulum
ER-SURF
membrane extraction
mitochondria
protein targeting
bimolecular luminescence complementation
competition
split luciferase
membrane proteins
protein–protein interactions
Sec61 complex
Sec63
synthetic peptide complementation
TRAP complex
ER protein translocase
signal peptide
protein translocation
nascent peptide chain
membrane insertion
molecular modelling
molecular dynamics simulations
molecular docking
signal peptidase
ER translocon
signal recognition particle dependent protein targeting
Sec61 dependent translocation
co-translational translocation
inhibitor
high throughput screening
Sec61
Sec62
folding
insertion
membrane protein
translocon
ribosome
transmembrane segment
lipid droplets
peroxisomes
PEX3
membrane protein insertion
label-free quantitative mass spectrometry
differential protein abundance analysis
Zellweger syndrome
GET
protein transport
SND
SRP
EMC
positive-inside rule
hydrophobicity
transmembrane helix
signal recognition particle
nascent polypeptide-associated complex
fidelity
cyclotriazadisulfonamide
ER quality control
DNAJC3
preprotein
Sec61 translocon
ribosome stalling
signal sequence
Sec61 translocase
NAC
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:ONIX_20220621_9783036540948_11
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