Protein-Ligand Interactions: Target Identification and Drug Discovery

Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of th...

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Bibliografiske detaljer
Format:	Online
Sprog:	engelsk
Udgivet:	MDPI - Multidisciplinary Digital Publishing Institute 2022
Fag:	serum half-life extension fatty acid conjugation FcRn-mediated recycling serum albumin translocator protein (TSPO) CoCl2 mitochondrial membrane potential reactive oxygen species (ROS) cell viability cell death lung cancer cell line acetylcholinesterase amyloid beta aggregation neuroprotection molecular docking multi-target drug structure–activity relationship brassicasterol phytosterols HSV Mycobacterium tuberculosis HSV-1 DNA polymerase HSV-1 TK human CDK2 ACE UDP-galactopyranose mutase heat shock protein 70 Hsp70 piperine fluorescence spectroscopy molecular dynamics molecular biophysics GADD45β MKK7 multiple myeloma protein-ligand interaction STD-NMR sigma receptors sigma ligands cancer SIGMAR1 PGRMC1 TMEM97 NCI60 COMPARE analysis membrane lipid-protein interaction lipid signalling kinase regulation phosphatidylinositols molecular docking simulation target identification small-molecule derivatives of salicylanilide drug discovery drug development thyroid diseases endocrine disruptor compound human umbilical artery vascular homeostasis thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PN Chemistry
Online adgang:	ONIX_20220111_9783036510507_344
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Protein-Ligand Interactions: Target Identification and Drug Discovery

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