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Intrinsically Disordered Proteins and Chronic Diseases

This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidatin...

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Médium: Online
Jazyk:angličtina
Vydáno: MDPI - Multidisciplinary Digital Publishing Institute 2022
Témata:
IDP
fuzzy interactions
protein complementation assays
split-GFP reassembly
kinetics
membraneless organelles
optical tweezer
liquid–liquid phase separation
protein diffusion
depletion interaction
entropic force
low-complexity sequences
intrinsically disordered proteins
PAGE4
conformational plasticity
order–disorder transition
phosphorylation
intrinsic disordered protein
extremely fuzzy complex
protein interaction
binding mechanism
tumor protein p53
mouse double minute 2
mouse double minute 4
Kinase-inducible domain interacting domain
phosphomimetics
nuclear magnetic resonance
transient secondary structure
COR15A
Late embryogenesis abundant
Trifluoroethanol
Nuclear magnetic resonance
intrinsically disordered regions
functional segments
disease-related proteins
protein-protein interaction
subcellular location
glucocorticoid receptor
intrinsically disordered
transactivation activity
gene regulation
coactivators
microtubule associated protein
tau
intrinsically disordered protein
dynamic configuration
free energy landscape
microtubules
electrostatics
diffusion
protein structure prediction
molecular modelling
molecular dynamics
tau–microtubule association
conformational ensemble
replica exchange molecular dynamics
drug design
n/a
thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
On-line přístup:ONIX_20220111_9783036512624_273
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Shrnutí:This book is an embodiment of a series of articles that were published as part of a Special Issue of Biomolecules. It is dedicated to exploring the role of intrinsically disordered proteins (IDPs) in various chronic diseases. The main goal of the articles is to describe recent progress in elucidating the mechanisms by which IDPs cause various human diseases, such as cancer, cardiovascular disease, amyloidosis, neurodegenerative diseases, diabetes, and genetic diseases, to name a few. Contributed by leading investigators in the field, this compendium serves as a valuable resource for researchers, clinicians as well as postdoctoral fellows and graduate students

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