Metastatic Progression and Tumour Heterogeneity
Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors...
Kaydedildi:
| Materyal Türü: | Online |
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| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Konular: | |
| Online Erişim: | ONIX_20210501_9783039288533_712 |
| Etiketler: |
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| _version_ | 1863742945751990272 |
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| collection | Directory of Open Access Books |
| description | Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors. |
| format | Online |
| id | doab-20.500.12854ir-68966 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-689662024-03-31T13:09:49Z Metastatic Progression and Tumour Heterogeneity Hollande, Fred Merino, Delphine clear cell renal cell carcinoma tumor evolution tumor ecology intratumor heterogeneity multisite tumor sampling targeted therapy uterine carcinosarcoma endometrial carcinoma metaplastic carcinoma epithelial-to-mesenchymal transition clonality mutation TP53 PI3K/AKT pathway gene expression miRNA expression tumor microenvironment interstitial pH acidosis tumor heterogeneity magnetic resonance imaging hyperpolarized 13C MRI carbonic anhydrase lactic acid positron emission tomography esophageal squamous cell carcinoma precision medicine natural killer cells tumor mutation burden immunotherapy PET heterogeneity radiomics radiopharmaceuticals SUV nuclear medicine colon cancer Wnt signaling phenotypic plasticity EMT hybrid E/M collective and single-cell migration beta-catenin paradox breast cancer immune microenvironment DCIS ADH mammary gland cell fate 3D cultures organoids signaling single-cell RNAseq tumor endothelial cell metastasis angiocrine factor microsatellite instability colorectal cancer immune checkpoints deficient mismatch repair plasticity biomechanics circulating tumor cells (CTCs) extracellular vesicles metastatic niche epigenetics CTC-clusters single-cell analysis cellular heterogeneity circulating tumor cells pancreatic cancer epithelial mesenchymal plasticity target discovery review genomics intra-tumour heterogeneity subclonal diversity treatment resistance thema EDItEUR::M Medicine and Nursing Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors. 2021-05-01T15:34:21Z 2021-05-01T15:34:21Z 2020 book ONIX_20210501_9783039288533_712 9783039288533 9783039288540 https://directory.doabooks.org/handle/20.500.12854/68966 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/2734 https://mdpi.com/books/pdfview/book/2734 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-854-0 10.3390/books978-3-03928-854-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039288533 9783039288540 312 Basel, Switzerland open access |
| spellingShingle | clear cell renal cell carcinoma tumor evolution tumor ecology intratumor heterogeneity multisite tumor sampling targeted therapy uterine carcinosarcoma endometrial carcinoma metaplastic carcinoma epithelial-to-mesenchymal transition clonality mutation TP53 PI3K/AKT pathway gene expression miRNA expression tumor microenvironment interstitial pH acidosis tumor heterogeneity magnetic resonance imaging hyperpolarized 13C MRI carbonic anhydrase lactic acid positron emission tomography esophageal squamous cell carcinoma precision medicine natural killer cells tumor mutation burden immunotherapy PET heterogeneity radiomics radiopharmaceuticals SUV nuclear medicine colon cancer Wnt signaling phenotypic plasticity EMT hybrid E/M collective and single-cell migration beta-catenin paradox breast cancer immune microenvironment DCIS ADH mammary gland cell fate 3D cultures organoids signaling single-cell RNAseq tumor endothelial cell metastasis angiocrine factor microsatellite instability colorectal cancer immune checkpoints deficient mismatch repair plasticity biomechanics circulating tumor cells (CTCs) extracellular vesicles metastatic niche epigenetics CTC-clusters single-cell analysis cellular heterogeneity circulating tumor cells pancreatic cancer epithelial mesenchymal plasticity target discovery review genomics intra-tumour heterogeneity subclonal diversity treatment resistance thema EDItEUR::M Medicine and Nursing Metastatic Progression and Tumour Heterogeneity |
| title | Metastatic Progression and Tumour Heterogeneity |
| title_full | Metastatic Progression and Tumour Heterogeneity |
| title_fullStr | Metastatic Progression and Tumour Heterogeneity |
| title_full_unstemmed | Metastatic Progression and Tumour Heterogeneity |
| title_short | Metastatic Progression and Tumour Heterogeneity |
| title_sort | metastatic progression and tumour heterogeneity |
| topic | clear cell renal cell carcinoma tumor evolution tumor ecology intratumor heterogeneity multisite tumor sampling targeted therapy uterine carcinosarcoma endometrial carcinoma metaplastic carcinoma epithelial-to-mesenchymal transition clonality mutation TP53 PI3K/AKT pathway gene expression miRNA expression tumor microenvironment interstitial pH acidosis tumor heterogeneity magnetic resonance imaging hyperpolarized 13C MRI carbonic anhydrase lactic acid positron emission tomography esophageal squamous cell carcinoma precision medicine natural killer cells tumor mutation burden immunotherapy PET heterogeneity radiomics radiopharmaceuticals SUV nuclear medicine colon cancer Wnt signaling phenotypic plasticity EMT hybrid E/M collective and single-cell migration beta-catenin paradox breast cancer immune microenvironment DCIS ADH mammary gland cell fate 3D cultures organoids signaling single-cell RNAseq tumor endothelial cell metastasis angiocrine factor microsatellite instability colorectal cancer immune checkpoints deficient mismatch repair plasticity biomechanics circulating tumor cells (CTCs) extracellular vesicles metastatic niche epigenetics CTC-clusters single-cell analysis cellular heterogeneity circulating tumor cells pancreatic cancer epithelial mesenchymal plasticity target discovery review genomics intra-tumour heterogeneity subclonal diversity treatment resistance thema EDItEUR::M Medicine and Nursing |
| topic_facet | clear cell renal cell carcinoma tumor evolution tumor ecology intratumor heterogeneity multisite tumor sampling targeted therapy uterine carcinosarcoma endometrial carcinoma metaplastic carcinoma epithelial-to-mesenchymal transition clonality mutation TP53 PI3K/AKT pathway gene expression miRNA expression tumor microenvironment interstitial pH acidosis tumor heterogeneity magnetic resonance imaging hyperpolarized 13C MRI carbonic anhydrase lactic acid positron emission tomography esophageal squamous cell carcinoma precision medicine natural killer cells tumor mutation burden immunotherapy PET heterogeneity radiomics radiopharmaceuticals SUV nuclear medicine colon cancer Wnt signaling phenotypic plasticity EMT hybrid E/M collective and single-cell migration beta-catenin paradox breast cancer immune microenvironment DCIS ADH mammary gland cell fate 3D cultures organoids signaling single-cell RNAseq tumor endothelial cell metastasis angiocrine factor microsatellite instability colorectal cancer immune checkpoints deficient mismatch repair plasticity biomechanics circulating tumor cells (CTCs) extracellular vesicles metastatic niche epigenetics CTC-clusters single-cell analysis cellular heterogeneity circulating tumor cells pancreatic cancer epithelial mesenchymal plasticity target discovery review genomics intra-tumour heterogeneity subclonal diversity treatment resistance thema EDItEUR::M Medicine and Nursing |
| url | ONIX_20210501_9783039288533_712 |