Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not on...
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| Format: | Online |
| Language: | English |
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Frontiers Media SA
2021
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| Online Access: | 18253 |
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| author | Pura Munoz-Canoves Jaime J. Carvajal Adolfo Lopez de Munain Ander Izeta |
| author_browse | Adolfo Lopez de Munain Ander Izeta Jaime J. Carvajal Pura Munoz-Canoves |
| author_facet | Pura Munoz-Canoves Jaime J. Carvajal Adolfo Lopez de Munain Ander Izeta |
| author_sort | Pura Munoz-Canoves |
| collection | Directory of Open Access Books |
| description | Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging. |
| format | Online |
| id | doab-20.500.12854ir-58607 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-586072024-04-05T12:36:21Z Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease Pura Munoz-Canoves Jaime J. Carvajal Adolfo Lopez de Munain Ander Izeta RC321-571 QH301-705.5 Q1-390 ageing satellite cell pericytes fibrosis myogenesis muscular dystrophies rejuvenation epigenetics muscle wasting sarcopenia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging. 2021-02-12T02:29:13Z 2021-02-12T02:29:13Z 2016-01-19 14:05:46 2016 book 18253 16648714 9782889198665 https://directory.doabooks.org/handle/20.500.12854/58607 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Role_of_Stem_Cells_in_Skeletal_Muscle_Development_Regeneration_Repair_Aging_and_Disease/909 http://journal.frontiersin.org/researchtopic/3021/role-of-stem-cells-in-skeletal-muscle-development-regeneration-repair-aging-and-disease Frontiers Media SA 10.3389/978-2-88919-866-5 10.3389/978-2-88919-866-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198665 220 open access |
| spellingShingle | RC321-571 QH301-705.5 Q1-390 ageing satellite cell pericytes fibrosis myogenesis muscular dystrophies rejuvenation epigenetics muscle wasting sarcopenia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Pura Munoz-Canoves Jaime J. Carvajal Adolfo Lopez de Munain Ander Izeta Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
| title | Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
| title_full | Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
| title_fullStr | Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
| title_full_unstemmed | Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
| title_short | Role of Stem Cells in Skeletal Muscle Development, Regeneration, Repair, Aging and Disease |
| title_sort | role of stem cells in skeletal muscle development regeneration repair aging and disease |
| topic | RC321-571 QH301-705.5 Q1-390 ageing satellite cell pericytes fibrosis myogenesis muscular dystrophies rejuvenation epigenetics muscle wasting sarcopenia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 QH301-705.5 Q1-390 ageing satellite cell pericytes fibrosis myogenesis muscular dystrophies rejuvenation epigenetics muscle wasting sarcopenia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18253 |
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