Novel Pharmacological Inhibitors for Bacterial Protein Toxins
Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action...
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| Formatua: | Online |
| Hizkuntza: | ingelesa |
| Argitaratua: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Gaiak: | |
| Sarrera elektronikoa: | 22408 |
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Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
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| _version_ | 1863731762802196480 |
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| author | Holger Barth |
| author_browse | Holger Barth |
| author_facet | Holger Barth |
| author_sort | Holger Barth |
| collection | Directory of Open Access Books |
| description | Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication. |
| format | Online |
| id | doab-20.500.12854ir-54883 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-548832024-04-05T12:31:55Z Novel Pharmacological Inhibitors for Bacterial Protein Toxins Holger Barth QH301-705.5 RA1190-1270 Bacterial AB-toxins infection Shiga toxin semicarbazone EGA pore-forming toxins Botulinum Neurotoxin (BoNT) black lipid bilayer membrane cellular uptake intracellular transport anthrax toxins Clostridium perfringens toxins Diphtheria toxin Clostridium difficile toxins pore-blockers sialidases translocation binary clostridial actin ADP-ribosylating toxins dendrimers clostridial toxins food-poisoning anti-toxins intestinal pathogenesis pharmacological inhibitors membrane transport probiotic microorganisms thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication. 2021-02-11T21:17:38Z 2021-02-11T21:17:38Z 2017-06-13 09:39:34 2017 book 22408 9783038424307 9783038424314 https://directory.doabooks.org/handle/20.500.12854/54883 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International http://sci.fo/36u http://www.mdpi.com/books/pdfview/book/314 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038424307 9783038424314 VI, 118 open access |
| spellingShingle | QH301-705.5 RA1190-1270 Bacterial AB-toxins infection Shiga toxin semicarbazone EGA pore-forming toxins Botulinum Neurotoxin (BoNT) black lipid bilayer membrane cellular uptake intracellular transport anthrax toxins Clostridium perfringens toxins Diphtheria toxin Clostridium difficile toxins pore-blockers sialidases translocation binary clostridial actin ADP-ribosylating toxins dendrimers clostridial toxins food-poisoning anti-toxins intestinal pathogenesis pharmacological inhibitors membrane transport probiotic microorganisms thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Holger Barth Novel Pharmacological Inhibitors for Bacterial Protein Toxins |
| title | Novel Pharmacological Inhibitors for Bacterial Protein Toxins |
| title_full | Novel Pharmacological Inhibitors for Bacterial Protein Toxins |
| title_fullStr | Novel Pharmacological Inhibitors for Bacterial Protein Toxins |
| title_full_unstemmed | Novel Pharmacological Inhibitors for Bacterial Protein Toxins |
| title_short | Novel Pharmacological Inhibitors for Bacterial Protein Toxins |
| title_sort | novel pharmacological inhibitors for bacterial protein toxins |
| topic | QH301-705.5 RA1190-1270 Bacterial AB-toxins infection Shiga toxin semicarbazone EGA pore-forming toxins Botulinum Neurotoxin (BoNT) black lipid bilayer membrane cellular uptake intracellular transport anthrax toxins Clostridium perfringens toxins Diphtheria toxin Clostridium difficile toxins pore-blockers sialidases translocation binary clostridial actin ADP-ribosylating toxins dendrimers clostridial toxins food-poisoning anti-toxins intestinal pathogenesis pharmacological inhibitors membrane transport probiotic microorganisms thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 RA1190-1270 Bacterial AB-toxins infection Shiga toxin semicarbazone EGA pore-forming toxins Botulinum Neurotoxin (BoNT) black lipid bilayer membrane cellular uptake intracellular transport anthrax toxins Clostridium perfringens toxins Diphtheria toxin Clostridium difficile toxins pore-blockers sialidases translocation binary clostridial actin ADP-ribosylating toxins dendrimers clostridial toxins food-poisoning anti-toxins intestinal pathogenesis pharmacological inhibitors membrane transport probiotic microorganisms thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 22408 |
| work_keys_str_mv | AT holgerbarth novelpharmacologicalinhibitorsforbacterialproteintoxins |