Hurdles for Phage Therapy (PT) to Become a Reality

Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant...

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Bibliographic Details
Main Author:	Brüssow, Harald
Format:	Online
Language:	English
Published:	MDPI - Multidisciplinary Digital Publishing Institute 2021
Subjects:	QH301-705.5 QR1-502 Q1-390 alginate abortive infection n/a bacterial resistance bacteriophages ATMP MALDI-MS adaptation Bacteriophage horizontal gene transfer adaptive immunity co-evolution Listeria ivanovii personalised medicines pH stability phage-human host interaction vB_SauM-fRuSau02 antimicrobial resistance phagodisinfection biofilm capsule depolymerase animal model phage cocktails Enterococcus cases report zoonosis resistance magistral formula experimental therapy Belgium phage therapy E. faecalis nontraditional antibacterial industrial phage application Democratic Republic of the Congo OrthoMCL Germany high-throughput sequencing antimicrobial infection antibiotic therapy Kayvirus phages Twortlikevirus bacterial disease human host Pseudomonas aeruginosa phage multidrug-resistant bacteria bacterial infection Salmonella Typhi rhamnopolysaccharide compassionate use crop production compounding pharmacy antimicrobial resistance (AMR) best practices bacteriophage efficacy phage sensitivity antibiotic-resistance antibiotic lysins PTMP Escherichia coli typhoid fever patent landscape phage preparation innate immunity anti-phage antibodies immunology Staphylococcus aureus global health clinical trial adsorption Brussels phage-resistance Galleria mellonella science communication history of science virus–host interactions foodborne illness prophage resistance management biofilms IND immunomodulation frequency of resistance capsule gastrointestinal tract phage-host interactions disinfection production bacteriophage therapy bacteriophage Staphylococcus magistral preparation extended-spectrum beta lactamases (ESBL) Viral proteins antibiotic resistance genomics phage biocontrol therapy target selection viral genomes evolution pharmaceutical paradigm shift personalized medicine pharmaceutical legislation food safety regulation virulence developing countries infectious disease regulatory framework sustainable agriculture Klebsiella pneumoniae thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Online Access:	42490
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Hurdles for Phage Therapy (PT) to Become a Reality

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