Brain Connectivity in Autism
The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intr...
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| Jazyk: | angličtina |
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Frontiers Media SA
2021
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| On-line přístup: | 17834 |
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| author | Lucina Q. Uddin Tal Kenet Ralph-Axel Muller Rajesh K. Kana Diane Chugani |
| author_browse | Diane Chugani Lucina Q. Uddin Rajesh K. Kana Ralph-Axel Muller Tal Kenet |
| author_facet | Lucina Q. Uddin Tal Kenet Ralph-Axel Muller Rajesh K. Kana Diane Chugani |
| author_sort | Lucina Q. Uddin |
| collection | Directory of Open Access Books |
| description | The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives. |
| format | Online |
| id | doab-20.500.12854ir-42413 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-424132024-04-05T17:29:49Z Brain Connectivity in Autism Lucina Q. Uddin Tal Kenet Ralph-Axel Muller Rajesh K. Kana Diane Chugani RC321-571 Q1-390 fMRI Pattern Classification white matter resting state development functional connectivity Brain connectivity Default Mode Network Autism Spectrum Disorders Diffusion Tensor Imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives. 2021-02-11T09:16:44Z 2021-02-11T09:16:44Z 2015-12-10 11:59:06 2014 book 17834 16648714 9782889192823 https://directory.doabooks.org/handle/20.500.12854/42413 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Brain_Connectivity_in_Autism/312#nogo http://journal.frontiersin.org/researchtopic/1107/brain-connectivity-in-autism Frontiers Media SA 10.3389/978-2-88919-282-3 10.3389/978-2-88919-282-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192823 264 open access |
| spellingShingle | RC321-571 Q1-390 fMRI Pattern Classification white matter resting state development functional connectivity Brain connectivity Default Mode Network Autism Spectrum Disorders Diffusion Tensor Imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Lucina Q. Uddin Tal Kenet Ralph-Axel Muller Rajesh K. Kana Diane Chugani Brain Connectivity in Autism |
| title | Brain Connectivity in Autism |
| title_full | Brain Connectivity in Autism |
| title_fullStr | Brain Connectivity in Autism |
| title_full_unstemmed | Brain Connectivity in Autism |
| title_short | Brain Connectivity in Autism |
| title_sort | brain connectivity in autism |
| topic | RC321-571 Q1-390 fMRI Pattern Classification white matter resting state development functional connectivity Brain connectivity Default Mode Network Autism Spectrum Disorders Diffusion Tensor Imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 fMRI Pattern Classification white matter resting state development functional connectivity Brain connectivity Default Mode Network Autism Spectrum Disorders Diffusion Tensor Imaging thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17834 |
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