Arthropod Venom Components and Their Potential Usage
Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e....
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Linkit: | 44849 |
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| author | Konno, Katsuhiro Rádis-Baptista, Gandhi |
| author_browse | Konno, Katsuhiro Rádis-Baptista, Gandhi |
| author_facet | Konno, Katsuhiro Rádis-Baptista, Gandhi |
| author_sort | Konno, Katsuhiro |
| collection | Directory of Open Access Books |
| description | Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads. |
| format | Online |
| id | doab-20.500.12854ir-41343 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
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| spelling | doab-20.500.12854ir-413432024-03-30T23:21:51Z Arthropod Venom Components and Their Potential Usage Konno, Katsuhiro Rádis-Baptista, Gandhi R5-920 RA1190-1270 n/a spider toxin hybrid immunogen channel-like pore-forming activity venom peptides chemotherapy piperidine heterocyclic amines computational docking insect immune system venom toxoplasmosis wasps ion channel structure mechanical allodynia Dinoponera quadriceps natural antibiotics bees acid-gated currents nematicide novel therapeutics toxins protons Hymenoptera venom ants chronic pain heart contractility transcriptome drug targets skin peptides LTQ Orbitrap Hybrid Mass Spectrometer cantharidin Centruroides limpidus Karch pilosulin-like peptide mechanism scorpion stent homology modelling amphipathic ?-helix structure Berberomeloe majalis mass spectrometric analysis phospholipases D Nav1.7 biotools metalloproteases myrmecology Tenebrio molitor antifeedant ixodicide virtual screening Loxosceles acid-sensing ion channels small hive beetle knottins Nav channel activity envenomation pharmacology Staphylococcus aureus spider venom scorpion venom insecticidal peptide Formicidae AMP de novo sequencing tertiapin leishmaniasis brown spider proteome keratitis Acinetobacter baumannii neuropathic pain bee venom bioinformatics ICK peptide human African trypanosomiasis automated patch-clamp Hymenoptera antimicrobial peptide LyeTxI-b linear cationic ?-helical peptide melittin Chagas disease mass spectrometry analysis neutralizing antibodies apoptosis protein–peptide interactions malaria pH regulation voltage-gated sodium channel venom toxicity insect neurotoxin solitary wasp oxaliplatin arthropod mastoparan cold allodynia pain target cutaneous disease pain NaV proteomics industrial biotechnology ant directed disulfide bond formation antivenoms blister beetle venom allergens ICK-like toxins Loxosceles spp. alternative treatment recombinant toxins FMRF-amide thema EDItEUR::M Medicine and Nursing Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads. 2021-02-11T08:30:57Z 2021-02-11T08:30:57Z 2020-04-07 23:07:09 2020 book 44849 9783039285402 9783039285419 https://directory.doabooks.org/handle/20.500.12854/41343 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2126 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-541-9 10.3390/books978-3-03928-541-9 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039285402 9783039285419 404 open access |
| spellingShingle | R5-920 RA1190-1270 n/a spider toxin hybrid immunogen channel-like pore-forming activity venom peptides chemotherapy piperidine heterocyclic amines computational docking insect immune system venom toxoplasmosis wasps ion channel structure mechanical allodynia Dinoponera quadriceps natural antibiotics bees acid-gated currents nematicide novel therapeutics toxins protons Hymenoptera venom ants chronic pain heart contractility transcriptome drug targets skin peptides LTQ Orbitrap Hybrid Mass Spectrometer cantharidin Centruroides limpidus Karch pilosulin-like peptide mechanism scorpion stent homology modelling amphipathic ?-helix structure Berberomeloe majalis mass spectrometric analysis phospholipases D Nav1.7 biotools metalloproteases myrmecology Tenebrio molitor antifeedant ixodicide virtual screening Loxosceles acid-sensing ion channels small hive beetle knottins Nav channel activity envenomation pharmacology Staphylococcus aureus spider venom scorpion venom insecticidal peptide Formicidae AMP de novo sequencing tertiapin leishmaniasis brown spider proteome keratitis Acinetobacter baumannii neuropathic pain bee venom bioinformatics ICK peptide human African trypanosomiasis automated patch-clamp Hymenoptera antimicrobial peptide LyeTxI-b linear cationic ?-helical peptide melittin Chagas disease mass spectrometry analysis neutralizing antibodies apoptosis protein–peptide interactions malaria pH regulation voltage-gated sodium channel venom toxicity insect neurotoxin solitary wasp oxaliplatin arthropod mastoparan cold allodynia pain target cutaneous disease pain NaV proteomics industrial biotechnology ant directed disulfide bond formation antivenoms blister beetle venom allergens ICK-like toxins Loxosceles spp. alternative treatment recombinant toxins FMRF-amide thema EDItEUR::M Medicine and Nursing Konno, Katsuhiro Rádis-Baptista, Gandhi Arthropod Venom Components and Their Potential Usage |
| title | Arthropod Venom Components and Their Potential Usage |
| title_full | Arthropod Venom Components and Their Potential Usage |
| title_fullStr | Arthropod Venom Components and Their Potential Usage |
| title_full_unstemmed | Arthropod Venom Components and Their Potential Usage |
| title_short | Arthropod Venom Components and Their Potential Usage |
| title_sort | arthropod venom components and their potential usage |
| topic | R5-920 RA1190-1270 n/a spider toxin hybrid immunogen channel-like pore-forming activity venom peptides chemotherapy piperidine heterocyclic amines computational docking insect immune system venom toxoplasmosis wasps ion channel structure mechanical allodynia Dinoponera quadriceps natural antibiotics bees acid-gated currents nematicide novel therapeutics toxins protons Hymenoptera venom ants chronic pain heart contractility transcriptome drug targets skin peptides LTQ Orbitrap Hybrid Mass Spectrometer cantharidin Centruroides limpidus Karch pilosulin-like peptide mechanism scorpion stent homology modelling amphipathic ?-helix structure Berberomeloe majalis mass spectrometric analysis phospholipases D Nav1.7 biotools metalloproteases myrmecology Tenebrio molitor antifeedant ixodicide virtual screening Loxosceles acid-sensing ion channels small hive beetle knottins Nav channel activity envenomation pharmacology Staphylococcus aureus spider venom scorpion venom insecticidal peptide Formicidae AMP de novo sequencing tertiapin leishmaniasis brown spider proteome keratitis Acinetobacter baumannii neuropathic pain bee venom bioinformatics ICK peptide human African trypanosomiasis automated patch-clamp Hymenoptera antimicrobial peptide LyeTxI-b linear cationic ?-helical peptide melittin Chagas disease mass spectrometry analysis neutralizing antibodies apoptosis protein–peptide interactions malaria pH regulation voltage-gated sodium channel venom toxicity insect neurotoxin solitary wasp oxaliplatin arthropod mastoparan cold allodynia pain target cutaneous disease pain NaV proteomics industrial biotechnology ant directed disulfide bond formation antivenoms blister beetle venom allergens ICK-like toxins Loxosceles spp. alternative treatment recombinant toxins FMRF-amide thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RA1190-1270 n/a spider toxin hybrid immunogen channel-like pore-forming activity venom peptides chemotherapy piperidine heterocyclic amines computational docking insect immune system venom toxoplasmosis wasps ion channel structure mechanical allodynia Dinoponera quadriceps natural antibiotics bees acid-gated currents nematicide novel therapeutics toxins protons Hymenoptera venom ants chronic pain heart contractility transcriptome drug targets skin peptides LTQ Orbitrap Hybrid Mass Spectrometer cantharidin Centruroides limpidus Karch pilosulin-like peptide mechanism scorpion stent homology modelling amphipathic ?-helix structure Berberomeloe majalis mass spectrometric analysis phospholipases D Nav1.7 biotools metalloproteases myrmecology Tenebrio molitor antifeedant ixodicide virtual screening Loxosceles acid-sensing ion channels small hive beetle knottins Nav channel activity envenomation pharmacology Staphylococcus aureus spider venom scorpion venom insecticidal peptide Formicidae AMP de novo sequencing tertiapin leishmaniasis brown spider proteome keratitis Acinetobacter baumannii neuropathic pain bee venom bioinformatics ICK peptide human African trypanosomiasis automated patch-clamp Hymenoptera antimicrobial peptide LyeTxI-b linear cationic ?-helical peptide melittin Chagas disease mass spectrometry analysis neutralizing antibodies apoptosis protein–peptide interactions malaria pH regulation voltage-gated sodium channel venom toxicity insect neurotoxin solitary wasp oxaliplatin arthropod mastoparan cold allodynia pain target cutaneous disease pain NaV proteomics industrial biotechnology ant directed disulfide bond formation antivenoms blister beetle venom allergens ICK-like toxins Loxosceles spp. alternative treatment recombinant toxins FMRF-amide thema EDItEUR::M Medicine and Nursing |
| url | 44849 |
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