Designing Next-Generation Drug-Like Molecules for Medicinal Applications

The development of new drugs/drug candidates for medical treatment remains an exciting but challenging process as only a limited number of synthetic compounds fit well into the discovery and development process after multiple experimentation and screening efforts in search of their preclinical prope...

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Bibliografiske detaljer
Format:	Online
Sprog:	engelsk
Udgivet:	MDPI - Multidisciplinary Digital Publishing Institute 2025
Fag:	anthraquinones antidiabetic antimicrobial Cassia obtusifolia L. hepatoprotection neuro protection spirooxindole azomethine ylides [3+2] cycloaddition reaction anti-cancer activity amide anti-inflammatory COX-2 iNOS NO PGE2 pyrazole quinoline thiosemicarbazone molecular design hybridization Alzheimer’s disease neurodegeneration drug therapy cholinesterases enzyme inhibition molecular docking diabetes drug delivery α-glucosidase in vivo studies α-mangostin nanosponges quasi-emulsion method HER4 ErbB4 cancer kinase inhibitors structure-activity relationship hesperetin derivatives PTP1B hesperetin 5-O-glucoside baricitinib bioavailability encapsulation hybrid nanoparticles poly(d,l-lactide-coglycolide) stearin anticancer kinase inhibitor neurodegenerative disorders deep machine learning generative modeling kinase inhibitor design Bruton’s tyrosine kinase covalent inhibitors 3-phenyl-β-alanine 1,3,4-oxadiazole hybrids carbonic anhydrase-II dental caries biofilm glucosyltransferases virtual screening antibiofilm antimicrobial ADMET profiling triterpenoic acid ursolic acid oleanolic acid betulinic acid rhodamine B rhodamine 101 cytotoxicity SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase FDA approved drugs molecular fingerprints structural similarity MD simulations MMPBSA immunomodulatory apoptosis in silico studies nicotinamide VEGFR-2 amino acyl coumarins (pseudo)-dipeptidyl coumarins carbonic anhydrases (CAs) monoamine oxidases (MAOs) iodinated histidines membrane active peptides anticryptococcal activity iodopeptides pore formation cell lysis antifungal agents n/a thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general thema EDItEUR::P Mathematics and Science::PH Physics::PHH Thermodynamics and heat
Online adgang:	ONIX_20250220_9783725830084_520
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Designing Next-Generation Drug-Like Molecules for Medicinal Applications

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