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Non-invasive Device-Mediated Brain Drug Delivery across the Blood-Brain Barrier

It is well known that the blood–brain barrier (BBB), substantially composed of tight junctions between the capillary endothelial cells and efflux transporters such as MDR1 at the apical membrane of the capillary endothelial cells, prevents drugs from entering the brain. Accordingly, drug delivery in...

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Salvato in:
Natura: Online
Lingua:inglese
Pubblicazione: MDPI - Multidisciplinary Digital Publishing Institute 2024
Soggetti:
glioblastoma
focused ultrasound
blood-brain barrier
PET
SPECT
drug delivery
rotigotine
lecithin-chitosan hybrid nanoparticles
intranasal delivery
nose-to-brain uptake
brain distribution study
in vitro model
blood–brain barrier (BBB)
nanoparticles
targeted receptor-mediated transcytosis
ligand conjugation
nicotinic acetylcholine receptor
nanobody
VHH
transferrin receptor
receptor-mediated transcytosis
nanoparticle
liposome
extracellular vesicle
chemotherapy
targeted therapy
blood–brain barrier
brain tumor
glioma
cell-penetrating peptides (CPPs)
endosomal entrapment
homing peptides
tumour-specific markers
siRNA-CPP delivery
porous silicon nanoparticles
BBB-on-a-chip
ligand density
organ-on-a-chip
nanomedicine
microfluidic model
neurodegenerative disorders
non-invasive delivery
device-related delivery
Alzheimer’s disease
Parkinson’s disease
ALS
Down syndrome
CNS disorders
nasal delivery
biologics
nose-to-brain
the blood–brain barrier
mesenchymal stem cell-based drug delivery
transmembrane drug delivery
n/a
thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering::TDCW Pharmaceutical chemistry and technology
Accesso online:ONIX_20240514_9783725806805_428
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ONIX_20240514_9783725806805_428

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