Ophthalmic Drug Delivery
Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challen...
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| Format: | Online |
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| Sprog: | engelsk |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online adgang: | ONIX_20231130_9783036587974_81 |
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| _version_ | 1863733673938911232 |
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| collection | Directory of Open Access Books |
| description | Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies. |
| format | Online |
| id | doab-20.500.12854ir-128629 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1286292024-03-31T13:10:23Z Ophthalmic Drug Delivery Otero-Espinar, Francisco Javier Ferreiro, Anxo Fernández excitotoxicity neurodegeneration retina microparticles controlled drug release rebamipide sustained delivery system dry eye eyelid mucin ocular pharmacokinetics ocular drug delivery systems ocular routes of drug administration intravitreal administration topical administration anti-angiogenesis corneal neovascularization (NV) epigallocatechin gallate (EGCG) gelatin hyaluronic acid (HA), nanoparticles RGD peptide eye drops retinal penetration neuroprotection protein aggregation stability intravitreal delivery CNTF corticosteroids drug delivery systems intravitreal dexamethasone implant intravitreal injections Ozurdex drug delivery glaucoma ROCK inhibitor fasudil PLGA microspheres intravitreal injection trabecular meshwork Schlemm’s canal retinal pigment epithelium Electric Cell-Substrate Impedance Sensing dexamethasone acetate cyclodextrins hydrogels rheology cytotoxicity studies transcorneal permeation radiolabeled ocular biopermanence blood-retinal barrier cationic drug transport lysosomal trapping atropine ophthalmic solution myopia amphotericin B γ-cyclodextrins fungal keratitis lutein PLGA PLGA–PEG–biotin ARPE-19 macular edema age-related macular degeneration biotin-decorated nanoparticles polymeric nanoparticles targeted therapy ocular drug delivery half-life extension albumin therapeutic proteins size exclusion chromatography iron retinal degeneration retinitis pigmentosa transferrin gene therapy plasmid electrotransfection dexamethasone poly(lactic-co-glycolic) acid ophthalmology microspheres periocular administration gamma sterilization tolerance in vitro model in vitro drug release intravitreal implants SLA 3D-printing triamcinolone acetonide USP apparatus 4 USP apparatus 7 vitreous substitute dissolution thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies. 2023-11-30T20:37:51Z 2023-11-30T20:37:51Z 2023 book ONIX_20231130_9783036587974_81 9783036587974 9783036587967 https://directory.doabooks.org/handle/20.500.12854/128629 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/8081 https://mdpi.com/books/pdfview/book/8081 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8796-7 10.3390/books978-3-0365-8796-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036587974 9783036587967 330 Basel open access |
| spellingShingle | excitotoxicity neurodegeneration retina microparticles controlled drug release rebamipide sustained delivery system dry eye eyelid mucin ocular pharmacokinetics ocular drug delivery systems ocular routes of drug administration intravitreal administration topical administration anti-angiogenesis corneal neovascularization (NV) epigallocatechin gallate (EGCG) gelatin hyaluronic acid (HA), nanoparticles RGD peptide eye drops retinal penetration neuroprotection protein aggregation stability intravitreal delivery CNTF corticosteroids drug delivery systems intravitreal dexamethasone implant intravitreal injections Ozurdex drug delivery glaucoma ROCK inhibitor fasudil PLGA microspheres intravitreal injection trabecular meshwork Schlemm’s canal retinal pigment epithelium Electric Cell-Substrate Impedance Sensing dexamethasone acetate cyclodextrins hydrogels rheology cytotoxicity studies transcorneal permeation radiolabeled ocular biopermanence blood-retinal barrier cationic drug transport lysosomal trapping atropine ophthalmic solution myopia amphotericin B γ-cyclodextrins fungal keratitis lutein PLGA PLGA–PEG–biotin ARPE-19 macular edema age-related macular degeneration biotin-decorated nanoparticles polymeric nanoparticles targeted therapy ocular drug delivery half-life extension albumin therapeutic proteins size exclusion chromatography iron retinal degeneration retinitis pigmentosa transferrin gene therapy plasmid electrotransfection dexamethasone poly(lactic-co-glycolic) acid ophthalmology microspheres periocular administration gamma sterilization tolerance in vitro model in vitro drug release intravitreal implants SLA 3D-printing triamcinolone acetonide USP apparatus 4 USP apparatus 7 vitreous substitute dissolution thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries Ophthalmic Drug Delivery |
| title | Ophthalmic Drug Delivery |
| title_full | Ophthalmic Drug Delivery |
| title_fullStr | Ophthalmic Drug Delivery |
| title_full_unstemmed | Ophthalmic Drug Delivery |
| title_short | Ophthalmic Drug Delivery |
| title_sort | ophthalmic drug delivery |
| topic | excitotoxicity neurodegeneration retina microparticles controlled drug release rebamipide sustained delivery system dry eye eyelid mucin ocular pharmacokinetics ocular drug delivery systems ocular routes of drug administration intravitreal administration topical administration anti-angiogenesis corneal neovascularization (NV) epigallocatechin gallate (EGCG) gelatin hyaluronic acid (HA), nanoparticles RGD peptide eye drops retinal penetration neuroprotection protein aggregation stability intravitreal delivery CNTF corticosteroids drug delivery systems intravitreal dexamethasone implant intravitreal injections Ozurdex drug delivery glaucoma ROCK inhibitor fasudil PLGA microspheres intravitreal injection trabecular meshwork Schlemm’s canal retinal pigment epithelium Electric Cell-Substrate Impedance Sensing dexamethasone acetate cyclodextrins hydrogels rheology cytotoxicity studies transcorneal permeation radiolabeled ocular biopermanence blood-retinal barrier cationic drug transport lysosomal trapping atropine ophthalmic solution myopia amphotericin B γ-cyclodextrins fungal keratitis lutein PLGA PLGA–PEG–biotin ARPE-19 macular edema age-related macular degeneration biotin-decorated nanoparticles polymeric nanoparticles targeted therapy ocular drug delivery half-life extension albumin therapeutic proteins size exclusion chromatography iron retinal degeneration retinitis pigmentosa transferrin gene therapy plasmid electrotransfection dexamethasone poly(lactic-co-glycolic) acid ophthalmology microspheres periocular administration gamma sterilization tolerance in vitro model in vitro drug release intravitreal implants SLA 3D-printing triamcinolone acetonide USP apparatus 4 USP apparatus 7 vitreous substitute dissolution thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| topic_facet | excitotoxicity neurodegeneration retina microparticles controlled drug release rebamipide sustained delivery system dry eye eyelid mucin ocular pharmacokinetics ocular drug delivery systems ocular routes of drug administration intravitreal administration topical administration anti-angiogenesis corneal neovascularization (NV) epigallocatechin gallate (EGCG) gelatin hyaluronic acid (HA), nanoparticles RGD peptide eye drops retinal penetration neuroprotection protein aggregation stability intravitreal delivery CNTF corticosteroids drug delivery systems intravitreal dexamethasone implant intravitreal injections Ozurdex drug delivery glaucoma ROCK inhibitor fasudil PLGA microspheres intravitreal injection trabecular meshwork Schlemm’s canal retinal pigment epithelium Electric Cell-Substrate Impedance Sensing dexamethasone acetate cyclodextrins hydrogels rheology cytotoxicity studies transcorneal permeation radiolabeled ocular biopermanence blood-retinal barrier cationic drug transport lysosomal trapping atropine ophthalmic solution myopia amphotericin B γ-cyclodextrins fungal keratitis lutein PLGA PLGA–PEG–biotin ARPE-19 macular edema age-related macular degeneration biotin-decorated nanoparticles polymeric nanoparticles targeted therapy ocular drug delivery half-life extension albumin therapeutic proteins size exclusion chromatography iron retinal degeneration retinitis pigmentosa transferrin gene therapy plasmid electrotransfection dexamethasone poly(lactic-co-glycolic) acid ophthalmology microspheres periocular administration gamma sterilization tolerance in vitro model in vitro drug release intravitreal implants SLA 3D-printing triamcinolone acetonide USP apparatus 4 USP apparatus 7 vitreous substitute dissolution thema EDItEUR::M Medicine and Nursing thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries |
| url | ONIX_20231130_9783036587974_81 |