Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators
Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecu...
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| Format: | Online |
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| Jezik: | engleski |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Online pristup: | ONIX_20230911_9783036581880_110 |
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| collection | Directory of Open Access Books |
| description | Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented. |
| format | Online |
| id | doab-20.500.12854ir-113977 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1139772024-03-31T13:08:13Z Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators Obrador, Elena Montoro, Alegria ferulic acid total body irradiation bone marrow microenvironment stem cell senescence bone marrow injury reactive oxygen species antioxidant defense system planarians model animal irradiation regeneration radioprotection radiation melatonin nDNA-repair mtDNA-mutations oxidation stress protection mitigation H2O2 ATP MDA GSH X-ray radiation 3T3 fibroblasts proliferation apoptosis cellular stress senescence peroxiredoxin 6 Prdx6 radioprotector pharmacologic ascorbate vitamin C pancreatic cancer Auranofin thioredoxin thioredoxin reductase peroxiredoxin nuclear and radiological emergencies radioprotectors radiomitigators radionuclide scavengers radiation biodosimetry Olea europaea L. cv. Caiazzana oleacein ionising radiation cancer radiotherapy normal tissue radiosensitization radiomodulation proteomic analysis oxidative modification profiling serum albumin amino acid sequences radiation biomarker human lactoferrin acute gamma irradiation C57Bl/6 mice survival rate open field test spleen serum homeostasis leukocytes stilbenoid electron paramagnetic resonance (EPR) FT-IR electron beam radiation radioresistance oxidative phosphorylation oncometabolites radiation response bioinformatics oxidative stress transcriptomics radiobiology database gene signature ionizing radiation intestine mucositis microbiome microbiota dysbiosis bacterial dietary supplement radiomitigator hyperthermia combination therapy synergistic effect oxygenation hypoxia immune response Tameron antioxidant n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented. 2023-09-11T12:15:31Z 2023-09-11T12:15:31Z 2023 book ONIX_20230911_9783036581880_110 9783036581880 9783036581897 https://directory.doabooks.org/handle/20.500.12854/113977 eng application/octet-stream Attribution 4.0 International https://mdpi.com/books/pdfview/book/7821 https://mdpi.com/books/pdfview/book/7821 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-8189-7 10.3390/books978-3-0365-8189-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036581880 9783036581897 322 open access |
| spellingShingle | ferulic acid total body irradiation bone marrow microenvironment stem cell senescence bone marrow injury reactive oxygen species antioxidant defense system planarians model animal irradiation regeneration radioprotection radiation melatonin nDNA-repair mtDNA-mutations oxidation stress protection mitigation H2O2 ATP MDA GSH X-ray radiation 3T3 fibroblasts proliferation apoptosis cellular stress senescence peroxiredoxin 6 Prdx6 radioprotector pharmacologic ascorbate vitamin C pancreatic cancer Auranofin thioredoxin thioredoxin reductase peroxiredoxin nuclear and radiological emergencies radioprotectors radiomitigators radionuclide scavengers radiation biodosimetry Olea europaea L. cv. Caiazzana oleacein ionising radiation cancer radiotherapy normal tissue radiosensitization radiomodulation proteomic analysis oxidative modification profiling serum albumin amino acid sequences radiation biomarker human lactoferrin acute gamma irradiation C57Bl/6 mice survival rate open field test spleen serum homeostasis leukocytes stilbenoid electron paramagnetic resonance (EPR) FT-IR electron beam radiation radioresistance oxidative phosphorylation oncometabolites radiation response bioinformatics oxidative stress transcriptomics radiobiology database gene signature ionizing radiation intestine mucositis microbiome microbiota dysbiosis bacterial dietary supplement radiomitigator hyperthermia combination therapy synergistic effect oxygenation hypoxia immune response Tameron antioxidant n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators |
| title | Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators |
| title_full | Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators |
| title_fullStr | Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators |
| title_full_unstemmed | Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators |
| title_short | Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators |
| title_sort | ionizing radiation antioxidant response and oxidative damage radiomodulators |
| topic | ferulic acid total body irradiation bone marrow microenvironment stem cell senescence bone marrow injury reactive oxygen species antioxidant defense system planarians model animal irradiation regeneration radioprotection radiation melatonin nDNA-repair mtDNA-mutations oxidation stress protection mitigation H2O2 ATP MDA GSH X-ray radiation 3T3 fibroblasts proliferation apoptosis cellular stress senescence peroxiredoxin 6 Prdx6 radioprotector pharmacologic ascorbate vitamin C pancreatic cancer Auranofin thioredoxin thioredoxin reductase peroxiredoxin nuclear and radiological emergencies radioprotectors radiomitigators radionuclide scavengers radiation biodosimetry Olea europaea L. cv. Caiazzana oleacein ionising radiation cancer radiotherapy normal tissue radiosensitization radiomodulation proteomic analysis oxidative modification profiling serum albumin amino acid sequences radiation biomarker human lactoferrin acute gamma irradiation C57Bl/6 mice survival rate open field test spleen serum homeostasis leukocytes stilbenoid electron paramagnetic resonance (EPR) FT-IR electron beam radiation radioresistance oxidative phosphorylation oncometabolites radiation response bioinformatics oxidative stress transcriptomics radiobiology database gene signature ionizing radiation intestine mucositis microbiome microbiota dysbiosis bacterial dietary supplement radiomitigator hyperthermia combination therapy synergistic effect oxygenation hypoxia immune response Tameron antioxidant n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | ferulic acid total body irradiation bone marrow microenvironment stem cell senescence bone marrow injury reactive oxygen species antioxidant defense system planarians model animal irradiation regeneration radioprotection radiation melatonin nDNA-repair mtDNA-mutations oxidation stress protection mitigation H2O2 ATP MDA GSH X-ray radiation 3T3 fibroblasts proliferation apoptosis cellular stress senescence peroxiredoxin 6 Prdx6 radioprotector pharmacologic ascorbate vitamin C pancreatic cancer Auranofin thioredoxin thioredoxin reductase peroxiredoxin nuclear and radiological emergencies radioprotectors radiomitigators radionuclide scavengers radiation biodosimetry Olea europaea L. cv. Caiazzana oleacein ionising radiation cancer radiotherapy normal tissue radiosensitization radiomodulation proteomic analysis oxidative modification profiling serum albumin amino acid sequences radiation biomarker human lactoferrin acute gamma irradiation C57Bl/6 mice survival rate open field test spleen serum homeostasis leukocytes stilbenoid electron paramagnetic resonance (EPR) FT-IR electron beam radiation radioresistance oxidative phosphorylation oncometabolites radiation response bioinformatics oxidative stress transcriptomics radiobiology database gene signature ionizing radiation intestine mucositis microbiome microbiota dysbiosis bacterial dietary supplement radiomitigator hyperthermia combination therapy synergistic effect oxygenation hypoxia immune response Tameron antioxidant n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | ONIX_20230911_9783036581880_110 |