Human Biomonitoring in Health Risk Assessment
Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable...
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| Sprache: | Englisch |
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MDPI - Multidisciplinary Digital Publishing Institute
2023
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| description | Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support. |
| format | Online |
| id | doab-20.500.12854ir-100018 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000182024-03-31T13:08:15Z Human Biomonitoring in Health Risk Assessment Rousselle, Christophe biomonitoring nanoparticles lung diseases mineralogical analysis of broncho-alveolar lavages occupational exposure human biomonitoring UV filters benzophenone-3 HBM4EU risk assessment RCR margin of safety oxidative stress MDA systematic review meta-analysis urinary biomarker reference range general population pesticides exposure operators workers residents bystanders tree-grown produce fruits vine systemic exposure paints production TiO2 powders biological monitoring exhaled breath condensate occupational health ortho-toluidine urinary mass-balance PBPK modelling human biomonitoring (HBM) internal exposure biomarkers endocrine disruptors bisphenol A (BPA) bisphenol S (BPS) bisphenols human biomonitoring guidance value (HBM-GV) physiologically based pharmacokinetic modelling (PBPK) organophosphorus flame retardants dietary exposure children malondialdehyde reference values benzene COVID-19 pandemic lockdown Rome elements urban traffic metabolomics dimethylformamide DMF HBM-GV guidance value biomarker toxicokinetics health effects liver carcinogenicity reprotoxic effects chlorpyrifos pesticide exposure pesticide risk assessment mercury methylmercury European Human Biomonitoring Initiative (HBM4EU) co-exposure workplace mixture risk assessment (MRA) adipose tissue meta-regression partition coefficients persistent organic pollutants n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support. 2023-05-11T17:16:55Z 2023-05-11T17:16:55Z 2023 book ONIX_20230511_9783036570044_35 9783036570044 9783036570051 https://directory.doabooks.org/handle/20.500.12854/100018 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7111 https://mdpi.com/books/pdfview/book/7111 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-7005-1 10.3390/books978-3-0365-7005-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036570044 9783036570051 284 Basel open access |
| spellingShingle | biomonitoring nanoparticles lung diseases mineralogical analysis of broncho-alveolar lavages occupational exposure human biomonitoring UV filters benzophenone-3 HBM4EU risk assessment RCR margin of safety oxidative stress MDA systematic review meta-analysis urinary biomarker reference range general population pesticides exposure operators workers residents bystanders tree-grown produce fruits vine systemic exposure paints production TiO2 powders biological monitoring exhaled breath condensate occupational health ortho-toluidine urinary mass-balance PBPK modelling human biomonitoring (HBM) internal exposure biomarkers endocrine disruptors bisphenol A (BPA) bisphenol S (BPS) bisphenols human biomonitoring guidance value (HBM-GV) physiologically based pharmacokinetic modelling (PBPK) organophosphorus flame retardants dietary exposure children malondialdehyde reference values benzene COVID-19 pandemic lockdown Rome elements urban traffic metabolomics dimethylformamide DMF HBM-GV guidance value biomarker toxicokinetics health effects liver carcinogenicity reprotoxic effects chlorpyrifos pesticide exposure pesticide risk assessment mercury methylmercury European Human Biomonitoring Initiative (HBM4EU) co-exposure workplace mixture risk assessment (MRA) adipose tissue meta-regression partition coefficients persistent organic pollutants n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology Human Biomonitoring in Health Risk Assessment |
| title | Human Biomonitoring in Health Risk Assessment |
| title_full | Human Biomonitoring in Health Risk Assessment |
| title_fullStr | Human Biomonitoring in Health Risk Assessment |
| title_full_unstemmed | Human Biomonitoring in Health Risk Assessment |
| title_short | Human Biomonitoring in Health Risk Assessment |
| title_sort | human biomonitoring in health risk assessment |
| topic | biomonitoring nanoparticles lung diseases mineralogical analysis of broncho-alveolar lavages occupational exposure human biomonitoring UV filters benzophenone-3 HBM4EU risk assessment RCR margin of safety oxidative stress MDA systematic review meta-analysis urinary biomarker reference range general population pesticides exposure operators workers residents bystanders tree-grown produce fruits vine systemic exposure paints production TiO2 powders biological monitoring exhaled breath condensate occupational health ortho-toluidine urinary mass-balance PBPK modelling human biomonitoring (HBM) internal exposure biomarkers endocrine disruptors bisphenol A (BPA) bisphenol S (BPS) bisphenols human biomonitoring guidance value (HBM-GV) physiologically based pharmacokinetic modelling (PBPK) organophosphorus flame retardants dietary exposure children malondialdehyde reference values benzene COVID-19 pandemic lockdown Rome elements urban traffic metabolomics dimethylformamide DMF HBM-GV guidance value biomarker toxicokinetics health effects liver carcinogenicity reprotoxic effects chlorpyrifos pesticide exposure pesticide risk assessment mercury methylmercury European Human Biomonitoring Initiative (HBM4EU) co-exposure workplace mixture risk assessment (MRA) adipose tissue meta-regression partition coefficients persistent organic pollutants n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology |
| topic_facet | biomonitoring nanoparticles lung diseases mineralogical analysis of broncho-alveolar lavages occupational exposure human biomonitoring UV filters benzophenone-3 HBM4EU risk assessment RCR margin of safety oxidative stress MDA systematic review meta-analysis urinary biomarker reference range general population pesticides exposure operators workers residents bystanders tree-grown produce fruits vine systemic exposure paints production TiO2 powders biological monitoring exhaled breath condensate occupational health ortho-toluidine urinary mass-balance PBPK modelling human biomonitoring (HBM) internal exposure biomarkers endocrine disruptors bisphenol A (BPA) bisphenol S (BPS) bisphenols human biomonitoring guidance value (HBM-GV) physiologically based pharmacokinetic modelling (PBPK) organophosphorus flame retardants dietary exposure children malondialdehyde reference values benzene COVID-19 pandemic lockdown Rome elements urban traffic metabolomics dimethylformamide DMF HBM-GV guidance value biomarker toxicokinetics health effects liver carcinogenicity reprotoxic effects chlorpyrifos pesticide exposure pesticide risk assessment mercury methylmercury European Human Biomonitoring Initiative (HBM4EU) co-exposure workplace mixture risk assessment (MRA) adipose tissue meta-regression partition coefficients persistent organic pollutants n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology |
| url | ONIX_20230511_9783036570044_35 |