Toxins
Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolu...
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| Формат: | Online |
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| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2023
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| Предметы: | |
| Online-ссылка: | ONIX_20230511_9783036569048_31 |
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Нет меток, Требуется 1-ая метка записи!
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| _version_ | 1863740944018309120 |
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| collection | Directory of Open Access Books |
| description | Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolution to acquire/improve their disabling/lethal effects, they display finely tuned functional properties often associated with high affinities and selectivity. Moreover, toxins are valuable tools to unravel cellular processes due to their extreme specificity for cell surface and/or intracellular targets. Therefore, toxins are very attractive compounds because of their Janus-like character; while they mostly act as deadly poisons like monstrous Mr. Hyde, they can also be tamed into good remedies like admirable Dr. Jekyll. As such, they have been primarily investigated not only for the light they can throw on fundamental physiological processes but also for their potential therapeutic applications. This reprint, emerging from the 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet.asso.fr/international), will be of great interest for those in the scientific community who want to know more about the fascinating world of toxins. |
| format | Online |
| id | doab-20.500.12854ir-100014 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-1000142024-03-31T13:08:16Z Toxins Ladant, Daniel Prévost, Gilles Popoff, Michel R. Benoit, Evelyne toxins peptide chemistry native chemical ligation α-bungarotoxin click chemistry automated patch-clamp fluorescent peptide TE671 cells nicotinic acetylcholine receptor animal toxin bacterial toxin marine toxin medical application plant toxin toxin function/activity toxin receptor/target toxin structure Debaryomyces hansenii Wickerhamomyces anomalus Saccharomyces cerevisiae PDR transporters killer toxin fetal adrenomedullary chromaffin cell gambierol potassium currents calcium-activated K+ channels ATP-sensitive K+ channels catecholamine release Clostridium tetani Clostridium botulinum botulinum neurotoxin tetanus neurotoxin toxin gene regulation two-component system small RNA adenylate cyclase toxin Bordetella pertussis cyclic nucleotide cAMP spectrophotometric enzymatic assay ASIC sodium channels peptide PcTx1 APETx2 MitTx mambalgin pain nociception clostridial C3 toxin C3bot C3botE174Q dendritic cells macrophages monocytes stimulated emission depletion (STED) super-resolution microscopy trained immunity effector-triggered immunity effector-triggered trained immunity staphylococcal superantigen enterotoxin toxin pathogenicity immunomodulation molecular and cellular targets n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolution to acquire/improve their disabling/lethal effects, they display finely tuned functional properties often associated with high affinities and selectivity. Moreover, toxins are valuable tools to unravel cellular processes due to their extreme specificity for cell surface and/or intracellular targets. Therefore, toxins are very attractive compounds because of their Janus-like character; while they mostly act as deadly poisons like monstrous Mr. Hyde, they can also be tamed into good remedies like admirable Dr. Jekyll. As such, they have been primarily investigated not only for the light they can throw on fundamental physiological processes but also for their potential therapeutic applications. This reprint, emerging from the 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet.asso.fr/international), will be of great interest for those in the scientific community who want to know more about the fascinating world of toxins. 2023-05-11T17:16:43Z 2023-05-11T17:16:43Z 2023 book ONIX_20230511_9783036569048_31 9783036569048 9783036569055 https://directory.doabooks.org/handle/20.500.12854/100014 eng image/jpeg Attribution 4.0 International https://mdpi.com/books/pdfview/book/7107 https://mdpi.com/books/pdfview/book/7107 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-0365-6905-5 10.3390/books978-3-0365-6905-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783036569048 9783036569055 226 Basel open access |
| spellingShingle | toxins peptide chemistry native chemical ligation α-bungarotoxin click chemistry automated patch-clamp fluorescent peptide TE671 cells nicotinic acetylcholine receptor animal toxin bacterial toxin marine toxin medical application plant toxin toxin function/activity toxin receptor/target toxin structure Debaryomyces hansenii Wickerhamomyces anomalus Saccharomyces cerevisiae PDR transporters killer toxin fetal adrenomedullary chromaffin cell gambierol potassium currents calcium-activated K+ channels ATP-sensitive K+ channels catecholamine release Clostridium tetani Clostridium botulinum botulinum neurotoxin tetanus neurotoxin toxin gene regulation two-component system small RNA adenylate cyclase toxin Bordetella pertussis cyclic nucleotide cAMP spectrophotometric enzymatic assay ASIC sodium channels peptide PcTx1 APETx2 MitTx mambalgin pain nociception clostridial C3 toxin C3bot C3botE174Q dendritic cells macrophages monocytes stimulated emission depletion (STED) super-resolution microscopy trained immunity effector-triggered immunity effector-triggered trained immunity staphylococcal superantigen enterotoxin toxin pathogenicity immunomodulation molecular and cellular targets n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology Toxins |
| title | Toxins |
| title_full | Toxins |
| title_fullStr | Toxins |
| title_full_unstemmed | Toxins |
| title_short | Toxins |
| title_sort | toxins |
| topic | toxins peptide chemistry native chemical ligation α-bungarotoxin click chemistry automated patch-clamp fluorescent peptide TE671 cells nicotinic acetylcholine receptor animal toxin bacterial toxin marine toxin medical application plant toxin toxin function/activity toxin receptor/target toxin structure Debaryomyces hansenii Wickerhamomyces anomalus Saccharomyces cerevisiae PDR transporters killer toxin fetal adrenomedullary chromaffin cell gambierol potassium currents calcium-activated K+ channels ATP-sensitive K+ channels catecholamine release Clostridium tetani Clostridium botulinum botulinum neurotoxin tetanus neurotoxin toxin gene regulation two-component system small RNA adenylate cyclase toxin Bordetella pertussis cyclic nucleotide cAMP spectrophotometric enzymatic assay ASIC sodium channels peptide PcTx1 APETx2 MitTx mambalgin pain nociception clostridial C3 toxin C3bot C3botE174Q dendritic cells macrophages monocytes stimulated emission depletion (STED) super-resolution microscopy trained immunity effector-triggered immunity effector-triggered trained immunity staphylococcal superantigen enterotoxin toxin pathogenicity immunomodulation molecular and cellular targets n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology |
| topic_facet | toxins peptide chemistry native chemical ligation α-bungarotoxin click chemistry automated patch-clamp fluorescent peptide TE671 cells nicotinic acetylcholine receptor animal toxin bacterial toxin marine toxin medical application plant toxin toxin function/activity toxin receptor/target toxin structure Debaryomyces hansenii Wickerhamomyces anomalus Saccharomyces cerevisiae PDR transporters killer toxin fetal adrenomedullary chromaffin cell gambierol potassium currents calcium-activated K+ channels ATP-sensitive K+ channels catecholamine release Clostridium tetani Clostridium botulinum botulinum neurotoxin tetanus neurotoxin toxin gene regulation two-component system small RNA adenylate cyclase toxin Bordetella pertussis cyclic nucleotide cAMP spectrophotometric enzymatic assay ASIC sodium channels peptide PcTx1 APETx2 MitTx mambalgin pain nociception clostridial C3 toxin C3bot C3botE174Q dendritic cells macrophages monocytes stimulated emission depletion (STED) super-resolution microscopy trained immunity effector-triggered immunity effector-triggered trained immunity staphylococcal superantigen enterotoxin toxin pathogenicity immunomodulation molecular and cellular targets n/a thema EDItEUR::M Medicine and Nursing thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology |
| url | ONIX_20230511_9783036569048_31 |