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Drug Metabolism, Pharmacokinetics and Bioanalysis
Publicado 2021“...Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. ...”
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Dual role of microglia in health and disease: pushing the balance towards repair
Publicado 2021“...Nevertheless, though substantial work has been devoted to microglia function, consensus around their exact origin, their role during development, as well as the exact nature of their interaction with other cells of the CNS has not been met.This issue discusses how microglial cells sustain neuronal activity and plasticity in the healthy CNS as well as the cellular and molecular mechanisms developed by microglia in response to injury and disease. ...”
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A dynamic interplay between membranes and the cytoskeleton critical for cell development and signaling
Publicado 2021“...Additional examples include recent genetic evidence that microtubule and actin filament interacting/regulatory proteins, such as MAP65-1 and capping protein, function as transducers of membrane lipid signaling into changes in cytoskeleton dynamics and organization. ...”
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Eating Disorders and Obesity: The Challenge for Our Times
Publicado 2021Subjects: “...family functioning...”
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Ecological Management of Pine Forests
Publicado 2021“...These approaches include the application of integrated methods for determining the reference conditions of the main functional and structural ecosystem components of forests. ...”
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Ecophysiology of root systems-environment interaction
Publicado 2021“...In this Research Topic, we aimed to provide an on-line, open-access snapshot of the current state of the art of the field of root ecology and physiology, with special focus on the translation of root structure to function, and how root systems are influenced by interplay with internal and external factors such as abiotic stress, microbes and plant-plant interaction. ...”
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Emergent Quantum Mechanics. David Bohm Centennial Perspectives
Publicado 2021Subjects: “...operator thermodynamic functions...”
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Emerging immune functions of non-hematopoietic stromal cells
Publicado 2021“...The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. ...”
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Energy metabolism and behavior in the corticotropin-releasing factor family of peptides
Publicado 2021“...Since Hans Selye's seminal work in the 1930s, there have been numerous advances with respect to our understanding of how the nervous and endocrine systems interact to help animals cope with stressors and how chronic stress may adversely impact health. ...”
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Environmental Tracers
Publicado 2021“...Water dating may invoke their characteristic decay or accumulation functions, (cf. radioactive and radiogenic compounds and isotopes) in a system or the characteristic injection of sources. ...”
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Epigenetic Modifications and Viral Infections
Publicado 2021“...In addition, in several cancers the down-regulation of tumor suppressor protein-coding genes and ncRNAs with growth inhibitory functions, such as miRNAs, have been closely linked to the presence of cell CpG island promoter hypermethylation. ...”
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Epigenetics of B Cells and Antibody Responses
Publicado 2021“...By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. ...”
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Ethylene: A Key Regulatory Molecule in Plants
Publicado 2021“...It influences performance of plants under optimal and stressful environments by interacting with other signaling molecules. Understanding the ethylene biosynthesis and action through the plant’s life can contribute to improve the knowledge of plant functionality and use of this plant hormone may drive adaptation and defense of plants from the adverse environmental conditions. ...”
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Evolution of NK-mediated target recognition under the pressure of physiologic or pathologic stimuli
Publicado 2021“...This finding early urged different groups to study the mechanisms governing NK cell function. The identification of the MHC-I-specific inhibitory receptors (i.e. ...”
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